0000000000325369

AUTHOR

Davide Ottolina

showing 2 related works from this author

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

2017

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurenc…

MalePediatricsHealth StatusOPERATING-ROOMRespiratory Tract DiseasesCHILDREN0302 clinical medicineREGIONAL ANESTHESIAPostoperative Complications030202 anesthesiologyCARDIAC-ARRESTMedicineGeneral anaesthesiaProspective StudiesProspective cohort studyChildIntraoperative ComplicationsCOMPLICATIONSddc:617Incidence (epidemiology)Mortality ratemusculoskeletal neural and ocular physiologyIncidenceAge FactorsHospitalsEuropeCardiovascular DiseasesChild PreschoolRESPIRATORY ADVERSE EVENTSFemaleClinical CompetenceCohort studyPulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentmacromolecular substancesAnesthesia GeneralDrug Hypersensitivity03 medical and health sciencesMORBIDITYJournal ArticleHumansbusiness.industryInfant NewbornInfant030208 emergency & critical care medicinePerioperativenervous systemPROSPECTIVE COHORTRelative riskRISK-FACTORSObservational studyHuman medicineNervous System DiseasesbusinessSYSTEM
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Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS

2021

Background Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant. Research Question Is the clinical application of sigh during pressure support ventilation (PSV) feasible? Study Design and Methods We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pr…

Pulmonary and Respiratory MedicineARDSbusiness.industryPressure support ventilationCritical Care and Intensive Care Medicinemedicine.diseaseSpontaneous breathing triallaw.invention03 medical and health sciences0302 clinical medicine030228 respiratory systemRandomized controlled triallawAnesthesiaBreathingMedicine030212 general & internal medicineCardiology and Cardiovascular MedicinebusinessRespiratory minute volumePositive end-expiratory pressureTidal volumeChest
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