0000000000325945
AUTHOR
Matthew Taylor
showing 3 related works from this author
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
2017
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurenc…
Philae's first days on the comet
2015
On 12 November 2014, Philae landed on the surface of comet 67P/Churyumov-Gerasimenko (67P), making an almost 30-year dream a reality. The pioneering flybys of 1P/Halley in 1986 revealed that despite being made primarily of ice, it was covered in highly absorbing carbonrich molecules. What is their composition? When did they form, and through which chemical routes? Might they have constituted prebiotic molecules necessary for life? At a larger scale, what can one learn from comets that has relevance to the evolution of the solar system and planets? ![Figure][1] 12 NOVEMBER 2014: PHILAE LANDED ON THE NUCLEUS OF COMET 67P CREDIT: ESA/ROSETTA/MPS FOR OSIRIS TEAM MPS/UPD/LAM/IAA/SSO/INTA/UPM/DAS…
Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase.
2018
BackgroundThere is uncertainty as to whether alterations in glutamatergic function in affective disorders differ between unipolar and bipolar disorders and between depressive and euthymic states. Additionally, there are currently no available blood-based markers of central glutamatergic function to support clinical diagnosis and aid brain based investigations. MethodsIn this study, we measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance Spectroscopy in medication free unipolar and bipolar patients (n=29, 20 unipolar and 9 bipolar) experiencing a major depressive episode, in comparison with a group of matched healthy controls (n=20). We als…