0000000000325996

AUTHOR

Philippe Lecomte

0000-0003-1040-7886

showing 3 related works from this author

A genomic map of climate adaptation in Mediterranean cattle breeds

2019

International audience; Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the structuring of genetic diversity of 21 autochtonous cattle breeds from the whole Mediterranean basin and performed genome-wide association analyses with covariables discriminating the different Mediterranean climate sub-types. This provided insights into both the demographic and adaptive histories of Mediterranean cattle. In particular, a detailed functional…

0106 biological sciences0301 basic medicineMediterranean climateCandidate genehttp://aims.fao.org/aos/agrovoc/c_24002Polymorphisme génétiqueAcclimatizationBreedingMediterraneanFacteur climatiquehttp://aims.fao.org/aos/agrovoc/c_11701 natural sciencesMediterranean Basinhttp://aims.fao.org/aos/agrovoc/c_4397http://aims.fao.org/aos/agrovoc/c_1081http://aims.fao.org/aos/agrovoc/c_3225Phylogeny2. Zero hungerGenomeEcology[SDV.BA]Life Sciences [q-bio]/Animal biologyhttp://aims.fao.org/aos/agrovoc/c_24031Chromosome MappingGenomicsSNP genotypingRace (animal)http://aims.fao.org/aos/agrovoc/c_3373http://aims.fao.org/aos/agrovoc/c_2080http://aims.fao.org/aos/agrovoc/c_4940http://aims.fao.org/aos/agrovoc/c_4026Génotypelocal adaptationBétailThermotoleranceBehavior and SystematicGenotypeP40 - Météorologie et climatologiehttp://aims.fao.org/aos/agrovoc/c_29554EvolutionIntrogressionSNPBiologyhttp://aims.fao.org/aos/agrovoc/c_259010603 evolutionary biology03 medical and health sciencescattle climate genetics local adaptation Mediterranean SNPhttp://aims.fao.org/aos/agrovoc/c_3081GeneticsAnimalsAdaptationhttp://aims.fao.org/aos/agrovoc/c_4697http://aims.fao.org/aos/agrovoc/c_8013climateEcology Evolution Behavior and SystematicsLocal adaptationGenetic diversityhttp://aims.fao.org/aos/agrovoc/c_2503Genetic Variation15. Life on landL10 - Génétique et amélioration des animauxClimat méditerranéen030104 developmental biologyGenetics PopulationEvolutionary biologycattleCarte génétiquehttp://aims.fao.org/aos/agrovoc/c_7273Adaptationgenetic
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Observatoire francophone des néoplasies endocriniennes multiples de type 1. Un outil du Groupe d'étude des Tumeurs Endocrines (GTE)

2007

Wermer's syndrome or Multiple Endocrine Neoplasia Type-1 (MEN1) is an autosomal dominant inherited disease, related to mutations in MEN1, an approximately 10-kb gene encoding menin, localized on chromosome 11q13. The Endocrine Tumor Group (GTE) has set up a MEN1 observatory of 1001 regularly followed MEN1 cases. This observatory aims at registering and evaluating MEN1 cases in a large cohort. Any new study on a particular unexplored aspect of the disease may be proposed by a physician to the GTE. This article describes the way to diagnose a new MEN1 case and to register it. Procedures for participating in a new study are presented. Some original results are quoted.

Gynecologycongenital hereditary and neonatal diseases and abnormalitiesendocrine systemmedicine.medical_specialtyPathologyEndocrine Tumorendocrine system diseasesbusiness.industryEndocrinology Diabetes and MetabolismGeneral Medicinemedicine.diseaseLarge cohortEndocrinologymedicineMEN1Inherited diseaseMultiple endocrine neoplasiabusinessAnnales d'Endocrinologie
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Ring opening polymerization of $\varepsilon$-caprolactone in the presence of wet $\beta$-cyclodextrin: Effect of the operative pressure and of water …

2016

International audience; The ring opening polymerization (ROP) of $\varepsilon$-caprolactone (CL) in the presence of $\beta$-cyclodextrin ($\beta$-CD) wasperformed in batch reactors both at room pressure and with the reaction system pressurized with CO$_2$, N$_2$ orAr. Significant enhancements of the polymerization rate was observed when the ROP was carried out withwet $\beta$-CD under pressure. For example, after 24 hours at 120° C with a $\beta$-CD/CL molar ratio of about1/100, the monomer conversion increased from 4 to 98–99% when the pressure was changed from 0.1to 12.5–13.0 MPa independent of the nature of the compressing gas. MALDI-TOF analyses indicated thata major fraction of polymer…

chemistry.chemical_classificationCyclodextrin010405 organic chemistryGeneral Chemical EngineeringChemistry (all)General ChemistryPolymer010402 general chemistry01 natural sciencesRing-opening polymerization0104 chemical scienceschemistry.chemical_compoundChain-growth polymerizationMonomerchemistryPolymerizationPolymer chemistryMolar mass distribution[CHIM]Chemical SciencesChemical Engineering (all)Caprolactone
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