0000000000326927

AUTHOR

Flavia Carle

showing 2 related works from this author

Developing and validating a novel multisource comorbidity score from administrative data: a large population-based cohort study from Italy

2017

ObjectiveTo develop and validate a novel comorbidity score (multisource comorbidity score (MCS)) predictive of mortality, hospital admissions and healthcare costs using multiple source information from the administrative Italian National Health System (NHS) databases.MethodsAn index of 34 variables (measured from inpatient diagnoses and outpatient drug prescriptions within 2 years before baseline) independently predicting 1-year mortality in a sample of 500 000 individuals aged 50 years or older randomly selected from the NHS beneficiaries of the Italian region of Lombardy (training set) was developed. The corresponding weights were assigned from the regression coefficients of a Weibull sur…

MaleDatabases FactualKaplan-Meier Estimate030204 cardiovascular system & hematologySettore MED/42 - Igiene Generale E ApplicataSeverity of Illness IndexState MedicineCohort Studies0302 clinical medicineHealth careMedicineHospital Mortality1506Settore SECS-S/05 - Statistica Sociale030212 general & internal medicineMedical diagnosisAged 80 and overeducation.field_of_studyHealth Care CostsGeneral MedicineMiddle Agedprognostic scoreHospitalizationcomorbidityItalyadministrative databaseRegression AnalysisFemaleRisk AdjustmentPublic HealthCohort studyPopulationDrug PrescriptionsSettore MED/01 - Statistica Medica03 medical and health sciencesHumans1724Medical prescriptioneducationSurvival analysisAgedReceiver operating characteristicbusiness.industryResearchmedicine.diseaseComorbidityROC Curverecord linkagebusinessDemographyBMJ Open
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A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease

2007

BACKGROUND: Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients. OBJECTIVE: The objective was to establish the safety threshold of prolonged exposure to trace amounts of gluten (ie, contaminating gluten). DESIGN: This was a multicenter, double-blind, placebo-controlled, randomized trial in 49 adults with biopsy-proven CD who were being treated with a gluten-free diet (GFD) for > or =2 y. The background daily gluten intake was maintained at < 5 mg. After a baseline evaluation (t0), patients were assigned to ingest daily for 90 d a capsule containing 0, 10, or 50 mg glute…

AdultMaleGluten free diet Celiac Diseasemedicine.medical_specialtyGlutensPlacebo-controlled studyMedicine (miscellaneous)gastroenterologyDiseasedigestive systemGastroenterologyCoeliac diseaselaw.inventionRandomized controlled trialDouble-Blind Methodgluten-free dietlawInternal medicineImmunopathologyIntestine SmallMedicineHumansgluten toxicitysmall-intestinal morphometryLymphocyte CountProspective StudiesIntestinal MucosaProspective cohort studyAutoantibodiesceliac disease; gastroenterology; gluten threshold in gluten-free food; gluten threshold in gluten-free food.; gluten toxicity; gluten-free diet; small-intestinal morphometrychemistry.chemical_classificationNutrition and DieteticsDose-Response Relationship Drugbusiness.industrynutritional and metabolic diseasesMiddle Agedmedicine.diseaseGlutendigestive system diseasesgluten threshold in gluten-free foodchemistryToxicityFemalebusinessceliac disease
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