0000000000330727
AUTHOR
Olivier Le Rouzic
showing 3 related works from this author
Factors associated with Pneumocystis colonization and circulating genotypes in chronic obstructive pulmonary disease patients with acute exacerbation…
2021
Abstract Pneumocystis jirovecii colonization is frequent during chronic obstructive pulmonary disease (COPD) and patients constitute potential contributors to its interhuman circulation. However, the existence of an environmental reservoir cannot be excluded. We assessed the prevalence and factors associated with Pneumocystis colonization during COPD, and studied circulation between patients and their domestic environment. Pneumocystis molecular detection and mtLSU genotyping were performed in oro-pharyngeal washes (OPW) sampled in 58 patients with COPD acute exacerbation, and in indoor dust, sampled in patients’ homes using electrostatic dust collectors (EDCs). Lung and systemic inflammati…
Impact of domestic mould exposure on Aspergillus biomarkers and lung function in patients with chronic obstructive pulmonary disease
2021
International audience; Patients with chronic obstructive pulmonary disease (COPD) are frequently colonised or sensitised by Aspergillus, but clinical significance remains unclear. Furthermore, little is known on the impact of indoor mould exposure during COPD. In this study, we assessed the relationship between domestic mould exposure, Aspergillus biomarkers and COPD severity during acute exacerbation and at stable state. Aspergillus section Fumigati culture in sputum and anti-Aspergillus antibodies detection (IgG and precipitins) were followed up in COPD patients that were prospectively recruited during exacerbation (n = 62), and underwent a visit at stable state after 18 months (n = 33).…
Impact de l’exposition domestique aux moisissures sur le risque de colonisation ou sensibilisation par Aspergillus fumigatus des patients atteints de…
2017
Objectif Les patients atteints de BPCO sont frequemment colonises par Aspergillus fumigatus (49–87 %) et a risque de developper des formes invasives d’aspergillose dont la mortalite est importante et l’incidence (environ 2 %) probablement sous-estimee. Afin de mieux comprendre le role de l’exposition environnementale aux moisissures dans ces infections, nous avons caracterise la flore fongique domiciliaire de patients atteints de BPCO et evalue son impact sur le risque de colonisation et sensibilisation fongiques par A. fumigatus . Methodes Soixante-deux patients ont ete prospectivement recrutes au CHRU de Lille entre aout 2011 et novembre 2015. La flore fongique domiciliaire a ete caracter…