0000000000331294

AUTHOR

Jose T. Real

showing 3 related works from this author

Genetic Variation at the ApoA-IV Gene Locus and Response to Diet in Familial Hypercholesterolemia

1998

Abstract —Plasma lipid response to dietary fat and cholesterol is, in part, genetically controlled. The apolipoprotein A-IV (apoA-IV protein; APOA4, gene) has been shown to influence the response to dietary changes in normolipidemic individuals. The response to diet in subjects with familial hypercholesterolemia (FH) is also variable, and no studies are available on the influence of APOA4 mutations on dietary response in these subjects. We studied the effect of 2 common apoA-IV genetic variants (Gln 360 →His and Thr 347 →Ser) on the lipid response to the National Cholesterol Education Program type I (NCEP-I) diet in 67 FH heterozygotes (43 women and 24 men). Subjects were studied at baseli…

AdultMaleHeterozygotemedicine.medical_specialtyVery low-density lipoproteinGenotypeApolipoprotein BHypercholesterolemiaFamilial hypercholesterolemiaStatistics Nonparametricchemistry.chemical_compoundHigh-density lipoproteinInternal medicinemedicineHumansAlleleNational Cholesterol Education ProgramAllelesApolipoproteins AGeneticsAnalysis of VariancebiologyCholesterolGenetic VariationMiddle Agedmedicine.diseaseDietary FatsLipidsEndocrinologychemistryLow-density lipoproteinMutationbiology.proteinFemalelipids (amino acids peptides and proteins)Cardiology and Cardiovascular MedicineArteriosclerosis, Thrombosis, and Vascular Biology
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Systemic inflammation in primary hypercholesterolemia results in platelet and leukocyte activation and their enhanced endothelial adhesiveness

2018

Primary hypercholesterolemiabusiness.industryApplied MathematicsGeneral MathematicsImmunologyMedicinePlateletmedicine.symptombusinessSystemic inflammationProceedings for Annual Meeting of The Japanese Pharmacological Society
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Absence of CCR3 receptor accelerates atherosclerosis in apoE-/- mice

2018

medicine.medical_specialtyEndocrinologyApoe micebusiness.industryApplied MathematicsGeneral MathematicsInternal medicineCCR3medicinebusinessReceptorProceedings for Annual Meeting of The Japanese Pharmacological Society
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