0000000000334898
AUTHOR
M. Knorr
ÉTUDE DE LA RÉACTION DE CYCLOADDITION DIPOLAIRE-1,3 DES YLURES D'AZOMÉTHINE N-MÉTALLES SUR LES 3-ARYLIDÈNE-1-PHÉNYLPYRROLIDINE- 2,5-DIONES
International audience
Synthèse et réactivité de 2-azabutadiènes fonctionnalisés. Application en chimie de coordination et organométallique
Coordination of unsaturated dithioethers to Cu(I) halides: From molecules to luminescent materials
Supplementary Material for: Characterization of New Organic Nitrate Hybrid Drugs Covalently Bound to Valsartan and Cilostazol
Background and Purpose: Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. With the present studies we synthesized and characterized new organic nitrate hybrid molecules. Compounds CLC-1265 (valsartan mononitrate) and CLC-1280 (valsartan dinitrate) are derivatives of the angiotensin receptor blocker valsartan, with CLC-1265 containing a single organic nitrate linker and CLC-1280 also containing a second, different linker. Compounds CLC-2000 (cilostazol mononitrate) and CLC-2100 (cilostazol dinitrate) are nitrate derivatives of the phosphodiesterase III inhibitor cilostazol. All compounds are designed as hybrid molecu…
CCDC 831548: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, A.Khatyr, M.Knorr, Y.Rousselin, M.M.Kubicki, Y.Mugnier, S.Richeter, P.Gerbier, C.Strohmann|2012|J.Organomet.Chem.|699|56|doi:10.1016/j.jorganchem.2011.10.034
CCDC 789006: Experimental Crystal Structure Determination
Related Article: M.Knorr, A.Pam, A.Khatyr, C.Strohmann, M.M.Kubicki, Y.Rousselin, S.M.Aly, D.Fortin, P.D.Harvey|2010|Inorg.Chem.|49|5834|doi:10.1021/ic901906h
CCDC 275791: Experimental Crystal Structure Determination
Related Article: S.Jacquot-Rousseau, G.Schmitt, A.Khatyr, M.Knorr, M.M.Kubicki, E.Vigier, O.Blacque|2006|Eur.J.Org.Chem.|2006|1555|doi:10.1002/ejoc.200500538
CCDC 265266: Experimental Crystal Structure Determination
Related Article: S.Jacquot-Rousseau, A.Khatyr, G.Schmitt, M.Knorr, M.M.Kubicki, O.Blacque|2005|Inorg.Chem.Commun.|8|610|doi:10.1016/j.inoche.2005.03.016
CCDC 275789: Experimental Crystal Structure Determination
Related Article: S.Jacquot-Rousseau, G.Schmitt, A.Khatyr, M.Knorr, M.M.Kubicki, E.Vigier, O.Blacque|2006|Eur.J.Org.Chem.|2006|1555|doi:10.1002/ejoc.200500538
CCDC 801247: Experimental Crystal Structure Determination
Related Article: M.Knorr, F.Guyon, M.M.Kubicki, Y.Rousselin, S.M.Aly, P.D.Harvey|2011|New J.Chem.|35|1184|doi:10.1039/c0nj00923g
CCDC 650184: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, M.Knorr, F.Villafane, C.Strohmann, M.M.Kubicki|2007|Eur.J.Inorg.Chem.||5052|doi:10.1002/ejic.200700470
Supplementary Material for: In vitro and in vivo Characterization of a New Organic Nitrate Hybrid Drug Covalently Bound to Pioglitazone
Background/Aims: Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor γ agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety. Methods: In vitro and in vivo characterization was performed by isometric tension recording, platelet function, bleeding time and detection of oxidative stress. Results: In vitro, CLC-3000 displayed more potent vasodilation than pioglitazone alone or classical nitrates. In vitro, some e…
CCDC 801246: Experimental Crystal Structure Determination
Related Article: M.Knorr, F.Guyon, M.M.Kubicki, Y.Rousselin, S.M.Aly, P.D.Harvey|2011|New J.Chem.|35|1184|doi:10.1039/c0nj00923g
CCDC 830378: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, A.Khatyr, M.Knorr, Y.Rousselin, M.M.Kubicki, Y.Mugnier, S.Richeter, P.Gerbier, C.Strohmann|2012|J.Organomet.Chem.|699|56|doi:10.1016/j.jorganchem.2011.10.034
CCDC 682379: Experimental Crystal Structure Determination
Related Article: R.Kinghat, A.Khatyr, G.Schmitt, M.Knorr, M.M.Kubicki, E.Vigier, F.Villafane|2008|Inorg.Chem.Commun.|11|1060|doi:10.1016/j.inoche.2008.05.022
CCDC 644866: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, M.Knorr, F.Villafane, C.Strohmann, M.M.Kubicki|2007|Eur.J.Inorg.Chem.||5052|doi:10.1002/ejic.200700470
CCDC 789009: Experimental Crystal Structure Determination
Related Article: M.Knorr, A.Pam, A.Khatyr, C.Strohmann, M.M.Kubicki, Y.Rousselin, S.M.Aly, D.Fortin, P.D.Harvey|2010|Inorg.Chem.|49|5834|doi:10.1021/ic901906h
CCDC 644869: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, M.Knorr, F.Villafane, C.Strohmann, M.M.Kubicki|2007|Eur.J.Inorg.Chem.||5052|doi:10.1002/ejic.200700470
CCDC 789008: Experimental Crystal Structure Determination
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CCDC 646158: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, M.Knorr, F.Villafane, C.Strohmann, M.M.Kubicki|2007|Eur.J.Inorg.Chem.||5052|doi:10.1002/ejic.200700470
CCDC 682377: Experimental Crystal Structure Determination
Related Article: R.Kinghat, A.Khatyr, G.Schmitt, M.Knorr, M.M.Kubicki, E.Vigier, F.Villafane|2008|Inorg.Chem.Commun.|11|1060|doi:10.1016/j.inoche.2008.05.022
CCDC 1045140: Experimental Crystal Structure Determination
Related Article: A.S. Mohamed, I. Jourdain, M. Knorr, Y. Rousselin, M.M. Kubicki|2015|Acta Crystallogr.,Sect.E:Cryst.Commun.|71|241|doi:10.1107/S2056989015001565
CCDC 644868: Experimental Crystal Structure Determination
Related Article: S.Clement, L.Guyard, M.Knorr, F.Villafane, C.Strohmann, M.M.Kubicki|2007|Eur.J.Inorg.Chem.||5052|doi:10.1002/ejic.200700470
CCDC 789005: Experimental Crystal Structure Determination
Related Article: M.Knorr, A.Pam, A.Khatyr, C.Strohmann, M.M.Kubicki, Y.Rousselin, S.M.Aly, D.Fortin, P.D.Harvey|2010|Inorg.Chem.|49|5834|doi:10.1021/ic901906h
CCDC 831549: Experimental Crystal Structure Determination
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CCDC 177466: Experimental Crystal Structure Determination
Related Article: F.Guyon, I.V.Jourdain, M.Knorr, D.Lucas, T.Monzon, Y.Mugnier, N.Avarvari, M.Fourmigue|2002|Eur.J.Inorg.Chem.||2026|doi:10.1002/1099-0682(200208)2002:8<2026::AID-EJIC2026>3.0.CO;2-0
CCDC 886242: Experimental Crystal Structure Determination
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CCDC 677529: Experimental Crystal Structure Determination
Related Article: R.Kinghat, H.Boudiba, A.Khatyr, M.Knorr, M.M.Kubicki|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o370|doi:10.1107/S1600536807066615
CCDC 644867: Experimental Crystal Structure Determination
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CCDC 275790: Experimental Crystal Structure Determination
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CCDC 789007: Experimental Crystal Structure Determination
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CCDC 177465: Experimental Crystal Structure Determination
Related Article: F.Guyon, I.V.Jourdain, M.Knorr, D.Lucas, T.Monzon, Y.Mugnier, N.Avarvari, M.Fourmigue|2002|Eur.J.Inorg.Chem.||2026|doi:10.1002/1099-0682(200208)2002:8<2026::AID-EJIC2026>3.0.CO;2-0
CCDC 682378: Experimental Crystal Structure Determination
Related Article: R.Kinghat, A.Khatyr, G.Schmitt, M.Knorr, M.M.Kubicki, E.Vigier, F.Villafane|2008|Inorg.Chem.Commun.|11|1060|doi:10.1016/j.inoche.2008.05.022
CCDC 789003: Experimental Crystal Structure Determination
Related Article: M.Knorr, A.Pam, A.Khatyr, C.Strohmann, M.M.Kubicki, Y.Rousselin, S.M.Aly, D.Fortin, P.D.Harvey|2010|Inorg.Chem.|49|5834|doi:10.1021/ic901906h
CCDC 265265: Experimental Crystal Structure Determination
Related Article: S.Jacquot-Rousseau, A.Khatyr, G.Schmitt, M.Knorr, M.M.Kubicki, O.Blacque|2005|Inorg.Chem.Commun.|8|610|doi:10.1016/j.inoche.2005.03.016
CCDC 789004: Experimental Crystal Structure Determination
Related Article: M.Knorr, A.Pam, A.Khatyr, C.Strohmann, M.M.Kubicki, Y.Rousselin, S.M.Aly, D.Fortin, P.D.Harvey|2010|Inorg.Chem.|49|5834|doi:10.1021/ic901906h
CCDC 886243: Experimental Crystal Structure Determination
Related Article: H.W.P.N'dongo, S.Clement, S.Richeter, F.Guyon, M.Knorr, P.l.Gendre, J.O.Bauer, C.Strohmann|2013|J.Organomet.Chem.|724|262|doi:10.1016/j.jorganchem.2012.11.022
CCDC 185833: Experimental Crystal Structure Determination
Related Article: M.Knorr, G.Schmitt, M.M.Kubicki, E.Vigier|2003|Eur.J.Inorg.Chem.||514|doi:10.1002/ejic.200390073