0000000000335057
AUTHOR
P. Indolfi
TUMORI a CELLULE GERMINALIin ETA' PEDIATRICA: FATTORI PROGNOSTICI del PROTOCOLLO AIEOP TCG 91.
CIRCA IL 20% DEI PAZIENTI CON TUMORI A CELLULE GERMINALI (tcg) SONO RESISTENTI AL TRATTAMENTO. GLI aUTORI HANNO EFFETTUATO UNO STUDIO POLICENTRICO AL FINE DI RILEVARE CORRELAZIONI TRA PARAMETRI CLINOCO/LABORATORISTICI E LA PROGNOSI
STAGE I GONADAL CELL TUMORS (GGCT): OUTCOME AFETR THE SURVEILLANCE STRATEGY AS APPLIED IN THE ASSOCIAZIONE ITALIANA EMATOLOGIA ONCOLOGIA PEDIATRICA (aieop) 2004 PROTOCOL
Suveillance strategy is a standerd option in stage 1° testicular GCT and suggested for ovarian GCT too. Worries regarding the relapse risk in ovarian are emerging. We here report on our series of stage 1° GGCT
Mature and immature teratoma: A report from the second Italian pediatric study
Background. Teratomas demonstrate a benign clinical behavior, however they may recur with malignant components or as teratoma, and in a small group of patients prognosis could be fatal. After the ®rst Italian study, we collected cases of teratoma, alongside the protocol for malignant germ cell tumors. Procedure. Patients with teratoma were collected from 2004 to 2014. Teratomas were classi®ed according to the WHO classi®cations, as mature and immature. Patients with pathological aFP and/or bHCG, and those with a malignant germ cell component were not included. Results. The study enrolled 219 patients (150 mature, 69 immature teratomas) with a median age at diagnosis of 42 months. The primar…
Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
BACKGROUND: Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. PROCEDURE: The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. RESULTS: The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondro…