Characterisation of the glycosidic linkage by infrared and Raman spectroscopy in the C-H stretching region: α,α-trehalose and α,α-trehalose-2,3,4,6,6-d10

Abstract I.r. and Raman spectra of solid α,α-trehalose and α,α-trehalose- 2,3,4,6,6-d 10 in the C-H and C-D stretching regions are recorded. The experimental data are reproduced satisfactorily by normal co-ordinate and i.r. absorption intensity calculations which take into account the specific interactions of each C-H hydrogen with nearby oxygen lone-pairs. The relevance of the region 2800–3000 cm −1 in α,α-trehalose- 2,3,4,6,6-d 10 for the study of the conformational properties of the inter-glycosidic linkage is discussed.