Effects of low temperature and pharmacological interventions on the responses of the isolated guinea-pig trachea

Cooling the guinea-pig isolated trachea from 37°C to 20°C virtually abolished the response to CaCl2 (in K+-depolarized tissues) and depressed that to histamine (about 75% reduction), KCl and 5-hydroxytryptamine (around 50% inhibition) while the response to acetylcholine remained unaffected. A further cooling to 10°C was necessary to inhibit acetylcholine-induced contractions. Hyporesponsiveness to spasmogens by cooling was not associated with subsensitivity (increased EC50) except for 5-hydroxytryptamine. Contractile responses to KCl (50 mmol/l), histamine (1 mmol/l) and 5-hydroxytryptamine (0.1 mmol/l) in a Ca2+-free EGTA (0.1 mmol/l)-containing solution were inhibited by cooling to 20°C b…

On the Dunford property (C) for bounded linear operators SR and RS

In this paper we show that if S in L(X; Y ) and R in L(Y;X), X and Y complex Banach spaces, then the products RS and SR share the Dunford property (C)

Polaroid type operators under quasi-affinies

We study the permanence of polaroid type conditions under quasi-affinities

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

Multi-band high resolution spectroscopy rules out the hot Jupiter BD+20 1790b - First data from the GIARPS Commissioning

Context. Stellar activity is currently challenging the detection of young planets via the radial velocity (RV) technique. Aims. We attempt to definitively discriminate the nature of the RV variations for the young active K5 star BD+20 1790, for which visible (VIS) RV measurements show divergent results on the existence of a substellar companion. Methods. We compare VIS data with high precision RVs in the near infrared (NIR) range by using the GIANO - B and IGRINS spectrographs. In addition, we present for the first time simultaneous VIS-NIR observations obtained with GIARPS (GIANO - B and HARPS - N) at Telescopio Nazionale Galileo (TNG). Orbital RVs are achromatic, so the RV amplitude does …

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (Intensive Care Medicine, (2016), 42, 12, (1865-1876), 10.1007/s00134-016-4571-5)

The members of the LUNG SAFE Investigators and the ESICM Trials Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error.

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study

Purpose: To evaluate patients with resolved versus confirmed ARDS, identify subgroups with substantial mortality risk, and to determine the utility of day 2 ARDS reclassification. Methods: Our primary objective, in this secondary LUNG SAFE analysis, was to compare outcome in patients with resolved versus confirmed ARDS after 24 h. Secondary objectives included identifying factors associated with ARDS persistence and mortality, and the utility of day 2 ARDS reclassification. Results: Of 2377 patients fulfilling the ARDS definition on the first day of ARDS (day 1) and receiving invasive mechanical ventilation, 503 (24%) no longer fulfilled the ARDS definition the next day, 52% of whom initial…

Les pathologies et accidents d’origine professionnelle dans les fonctions publiques : de la déclaration à la réparation et les acteurs économiques

Observation of the suppression of the flux of cosmic rays above 4x10^19eV

The energy spectrum of cosmic rays above 2.5 × 10¹⁸ eV, derived from 20,000 events recorded at the Pierre Auger Observatory, is described. The spectral index γ of the particle flux, J ∝ E-γ, at energies between 4 × 10¹⁸ eV and 4 × 10¹⁹ eV is 2.69 ± 0.02(stat) ± 0.06(syst), steepening to 4.2 ± 0.4(stat) ± 0.06(syst) at higher energies. The hypothesis of a single power law is rejected with a significance greater than 6 standard deviations. The data are consistent with the prediction by Greisen and by Zatsepin and Kuz'min.

Correlation of the highest-energy cosmic rays with nearby extragalactic objects.

Using data collected at the Pierre Auger Observatory during the past 3.7 years, we demonstrated a correlation between the arrival directions of cosmic rays with energy above ~ 6x10^{19} electron volts and the positions of active galactic nuclei (AGN) lying within ~ 75 megaparsecs. We rejected the hypothesis of an isotropic distribution of these cosmic rays with at least a 99% confidence level from a prescribed a priori test. The correlation we observed is compatible with the hypothesis that the highest energy particles originate from nearby extragalactic sources whose flux has not been substantially reduced by interaction with the cosmic background radiation. AGN or objects having a similar…

Upper limit on the cosmic-ray photon flux above 1019 eV using the surface detector of the Pierre Auger Observatory

A method is developed to search for air showers initiated by photons using data recorded by the surface detector of the Auger Observatory. The approach is based on observables sensitive to the longitudinal shower development, the signal risetime and the curvature of the shower front. Applying this method to the data, upper limits on the flux of photons of 3.8 x 10-3, 2.5 x 10-3; and 2.2 x 10-3 km-2 sr-1 yr-1 above 1019 eV, 2 x 1019 eV; and 4 x 1019 eV are derived, with corresponding limits on the fraction of photons being 2.0%, 5.1%, and 31% (all limits at 95% c.l.). These photon limits disfavor certain exotic models of sources of cosmic rays. The results also show that the approach adopted…

Correlation of the highest-energy cosmic rays with the positions of nearby active galactic nuclei

Data collected by the Pierre Auger Observatory provide evidence for anisotropy in the arrival directions of the cosmic rays with the ighest-energies, which are correlated with the positions of relatively nearby active galactic nuclei (AGN) [Pierre Auger Collaboration, Science 318 (2007) 938]. The correlation has maximum significance for cosmic rays with energy greater than ~6 x 1019 eV and AGN at a distance less than ~75 Mpc. We have confirmed the anisotropy at a confidence level of more than 99% through a test with parameters specified a priori, using an independent data set. The observed correlation is compatible with the hypothesis that cosmic rays with the highest-energies originate fro…

CCDC 224410: Experimental Crystal Structure Determination

Related Article: S.Ferrer, R.Ballesteros, A.Sambartolome, M.Gonzalez, G.Alzuet, J.Borras, M.Liu|2004|J.Inorg.Biochem.|98|1436|doi:10.1016/j.jinorgbio.2004.05.004

CCDC 224408: Experimental Crystal Structure Determination

Related Article: S.Ferrer, R.Ballesteros, A.Sambartolome, M.Gonzalez, G.Alzuet, J.Borras, M.Liu|2004|J.Inorg.Biochem.|98|1436|doi:10.1016/j.jinorgbio.2004.05.004

CCDC 224409: Experimental Crystal Structure Determination

Related Article: S.Ferrer, R.Ballesteros, A.Sambartolome, M.Gonzalez, G.Alzuet, J.Borras, M.Liu|2004|J.Inorg.Biochem.|98|1436|doi:10.1016/j.jinorgbio.2004.05.004