0000000000343284

AUTHOR

Christine Mian

showing 4 related works from this author

Nomograms including nuclear matrix protein 22 for prediction of disease recurrence and progression in patients with Ta, T1 or CIS transitional cell c…

2005

ABSTRACT Purpose: We developed and validated nomograms that accurately predict disease recurrence and progression in patients with Ta, T1, or CIS transitional cell carcinoma (TCC) of the bladder using a large international cohort. Methods: Univariate and multivariate logistic regression models targeted histologically confirmed disease recurrence, and focused on 2,542 patients with bladder TCC from 10 participating centers. Variables consisted of pre-cystoscopy voided urine Nuclear Matrix Protein 22 (NMP22) assay, urine cytology, age and gender. Resulting nomograms were internally validated with bootstrapping. Nomogram performance was explored graphically with Loess smoothing plots. Results:…

AdultMalemedicine.medical_specialtyAdolescentUrologyUrinary systemUrologyurologic and male genital diseasesLogistic regressionBladder neoplasmsnuclear matrix protein 22neoplasm stagingnomogramsBladder NeoplasmCytologyBiomarkers TumormedicineHumansStage (cooking)AgedNeoplasm StagingUrine cytologyAged 80 and overCarcinoma Transitional Cellmedicine.diagnostic_testbusiness.industryNuclear ProteinsMiddle AgedNomogramPrognosismedicine.diseasefemale genital diseases and pregnancy complicationsSurgeryNomogramsTransitional cell carcinomaUrinary Bladder NeoplasmsMultivariate AnalysisDisease ProgressionFemalebusiness
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Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma

2008

OBJECTIVE: To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC). PATIENTS AND METHODS: We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents. RESULTS: The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test…

AdultMalemedicine.medical_specialtyAdolescentUrologyUrinary systemUrologyContext (language use)urologic and male genital diseasesSensitivity and SpecificityCohort StudiesPredictive Value of TestsRisk FactorsCytologyBiomarkers TumormedicineCarcinomaHumansChildAgedRetrospective StudiesAged 80 and overGynecologyBladder cancerbusiness.industryNuclear ProteinsMiddle AgedPrognosismedicine.diseaseTransitional cell carcinomaUrinary Bladder NeoplasmsEpidermoid carcinomaPredictive value of testsCarcinoma Squamous CellFemaleNeoplasm Recurrence LocalbusinessBJU International
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Variability in the performance of nuclear matrix protein 22 for the detection of bladder cancer.

2006

PURPOSE: We assessed variability in the diagnostic performance of NMP22 for detecting recurrence and progression in patients with Ta, T1, and/or CIS transitional cell carcinoma of the bladder in a large international cohort. MATERIALS AND METHODS: NMP22 voided urine levels were measured in 2,871 patients who underwent office cystoscopy for monitoring previous stage Ta, T1 and/or CIS transitional cell carcinoma at 12 participating institutions. RESULTS: Patient characteristics varied considerably among institutions. Overall 1,045 patients (36.4%) had recurrent transitional cell carcinoma (range across institutions 13.6% to 54.3%). Median NMP22 was 5.5 U/ml (range across institutions 2.5 to 1…

AdultMalemedicine.medical_specialtyUrologyUrinary systemnuclear matrix protein 22Urologytumor markers biologicalBladder NeoplasmBiomarkers TumorMedicineHumansStage (cooking)bladderAgedGynecologyAged 80 and overCarcinoma Transitional CellUrinary bladderBladder cancermedicine.diagnostic_testbusiness.industryCarcinoma in situNuclear ProteinsReproducibility of ResultsCystoscopyMiddle Agedmedicine.diseasemedicine.anatomical_structureTransitional cell carcinomaUrinary Bladder NeoplasmsDisease Progressionbladder neoplasmFemaleNeoplasm Recurrence LocalbusinessThe Journal of urology
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Teaching transurethral resection of the bladder: still a challenge?

2003

Abstract Objectives To report on our 2-year experience in teaching transurethral resection (TUR) of bladder tumors to five trainees. We analyzed their problems, as well as those of the teachers, and present our solutions. Methods Between April 2000 and March 2002, five residents and three members of the staff took part in a training program to teach TUR of the bladder. From a total of 692 patients with bladder tumors admitted for treatment to our department, 417 were selected for the study. These 417 had papillary tumors of small to medium size (maximum 25 mm in diameter). The mean patient age was 61 years (range 32 to 92) for men (n = 322; 77%) and 68.4 years (range 48 to 91) for women (n …

AdultMalemedicine.medical_specialtyUrologyUrinary BladdereducationPerforation (oil well)ResectionPostoperative ComplicationsPatient ageHumansMedicineProspective StudiesAgedAged 80 and overUrinary bladderSurgical approachbusiness.industryInternship and ResidencyMiddle AgedCarcinoma PapillarySurgerymedicine.anatomical_structureUrethraUrinary Bladder NeoplasmsGeneral SurgeryUrologic Surgical ProceduresEducation Medical ContinuingFemalebusinessTraining programComplicationProgram EvaluationUrology
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