0000000000343703
AUTHOR
Hartmut Schäfer
showing 2 related works from this author
Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups.
2010
Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease exhibiting variable clinical course and survival rates. Mutational status of the immunoglobulin heavy chain variable regions (IGHVs) of CLL cells offers useful prognostic information for high-risk patients, but time and economical costs originally prevented it from being routinely used in a clinical setting. Instead, alternative markers of IGHV status, such as zeta-associated protein (ZAP70) or messenger RNA levels are often used. We report a (1)H-NMR-based metabolomics approach to examine serum metabolic profiles of early stage, untreated CLL patients (Binet stage A) classified on the basis of IGHV mutational status or ZAP70. M…
Konformation sterisch gehinderter Anilin-Kationradikale und Benzyl-Kationen/On the Conformation of Sterically Hindered Aniline Cation Radicals and Be…
1979
Abstract A series of aniline cation radicals have been generated in a flow apparatus, and their ESR spectra have been recorded and interpreted. The data show that the NR1R2 substituents are less twisted in these systems than the CR1R2 substituents in the isoelectronic but sterically less hindered benzyl radicals, in accordance with MNDO calculations. The conformations of these systems are strongly influenced by electronic π-resonance effects which limit the usefulness of steric models for structural predictions. The results suggest that the CR1R2 substituent in the benzyl cations is less twisted than in the corresponding radicals. An ESR measurement of these radicals should therefore provid…