0000000000345220

AUTHOR

Sebastian Kölmel

showing 3 related works from this author

Potential Involvement of Osteopontin in Inflammatory and Fibrotic Processes in Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension

2019

Background Inflammation and incomplete thrombus resolution leading to obstructive fibrotic remodelling are considered critical mechanisms for the development of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE). Osteopontin (OPN) is involved in a variety of biological processes including inflammation and tissue fibrosis. Methods OPN plasma concentrations were measured in 70 CTEPH and 119 PE patients. Tissue material from 6 CTEPH patients removed during pulmonary endarterectomy and murine venous thrombi induced by subtotal ligation of the inferior vena cava in C57BL/6 mice were analysed by (immuno)histochemistry. Results CTEPH patients had higher OPN plasma…

Male0301 basic medicinePathologymedicine.medical_specialtyHypertension Pulmonarymedicine.medical_treatmentInflammationEndarterectomy030204 cardiovascular system & hematologyInferior vena cavaTranslational Research BiomedicalPathogenesisMice03 medical and health sciences0302 clinical medicinestomatognathic systemFibrosisThromboembolismmedicineAnimalsHumansProspective StudiesOsteopontinThrombusMyofibroblastsAgedEndarterectomyInflammationbiologybusiness.industryThrombosisHematologyMiddle AgedPrognosismedicine.diseaseFibrosisPulmonary embolismMice Inbred C57BL030104 developmental biologymedicine.veinChronic Diseasebiology.proteinFemaleOsteopontinmedicine.symptomPulmonary EmbolismbusinessBiomarkersThrombosis and Haemostasis
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Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.

2018

Management and outcome of patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) who underwent pulmonary endarterectomy (PEA) at a large German referral center were investigated.In Germany, 394 PEAs were performed in 2014 and 2015 with an in-hospital mortality rate of 5.8%. Of these, 253 patients (64.2%) were treated at the Kerckhoff Clinic, Bad Nauheim, and 237 (93.7%; median age, 62 years [interquartile range [IQR], 52-72 years]; 46.0% female) were included in the present analysis.On referral, 52 patients (22.0%) were treated with pulmonary arterial hypertension-specific drugs and 95 (40.4%) were treated with non-vitamin K-dependent oral anticoagulants, and 14 (5.9%)…

Pulmonary and Respiratory MedicineTransplantationmedicine.medical_specialtyReferralbusiness.industryMortality rate030204 cardiovascular system & hematologySurgeryPulmonary endarterectomy03 medical and health sciences0302 clinical medicine030228 respiratory systemInterquartile rangemedicine.arteryPulmonary arteryMedicineReferral centerSurgeryChronic thromboembolic pulmonary hypertensionCardiology and Cardiovascular MedicinebusinessThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
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Risk factors for chronic thromboembolic pulmonary hypertension – Importance of thyroid disease and function

2019

Abstract Introduction Although a number of risk factors for chronic thromboembolic pulmonary hypertension (CTEPH) have been reported, the exact prevalence is controversial and varies between published cohorts. The aim of the present study was to investigate the prevalence of risk factors in operable CTEPH patients with special emphasis on thyroid disease and function. Material and methods Overall, 228 CTEPH patients (47.7% female; median age 63 [IQR 52–72] years) scheduled for pulmonary endarterectomy between 01/2014 and 12/2015 were studied. Prevalence of risk factors was assessed, and patients were classified according to their thyroid function based on laboratory measurements. Results As…

Malemedicine.medical_specialtyendocrine system diseasesHypertension PulmonaryLevothyroxineCardiac index030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineHumansEuthyroidRisk factorAgedbusiness.industryThyroid diseaseHematologyMiddle Agedmedicine.diseaseThyroid DiseasesPulmonary embolism030220 oncology & carcinogenesisChronic DiseaseFemaleChronic thromboembolic pulmonary hypertensionThyroid functionPulmonary Embolismbusinessmedicine.drugThrombosis Research
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