0000000000347337
AUTHOR
R. Higueras
Epidural anesthesia: Simulated intravascular test dose with S(+) ketamine, lidocaine and adrenaline. A prospective, randomized, double blind and placebo controlled study
Abstract Objective The use of a test dose in epidural anesthesia is a safety recommendation. However, specificity and sensitivity of the drugs used with this indication have not been conclusive. The main objective of this study was to compare the effectiveness and the adverse effects of a simulated intravascular test dose of adrenaline, lidocaine and S(+)-ketamine. Material and methods A prospective, randomized, double blinded, placebo controlled study was designed. ASA I patients scheduled for elective surgery were included. These were randomized to the following study groups: S(+)-ketamine 0.5 mg kg −1 (S+K group), 5% lidocaine 1.5 mg kg −1 (L5% group), adrenaline 15 μg (ADR group), and p…
Anestesia epidural: dosis test intravascular simulada con S(+)-ketamina, lidocaína y adrenalina. Estudio prospectivo, aleatorizado, doble ciego, controlado con placebo
ResumenObjetivo La dosis test en anestesia epidural es una recomendacion de seguridad. La especificidad y sensibilidad de los farmacos empleados no ha resultado concluyente. Nuestro objetivo fue comparar la efectividad de adrenalina, lidocaina y S(+)-ketamina como dosis test intravascular simulada, asi como sus efectos adversos. Material y metodos Estudio prospectivo, aleatorizado, doble ciego, controlado con placebo. Pacientes ASA I, sometidos a cirugia electiva. Los grupos de estudio fueron (asignacion aleatoria): S(+)-ketamina 0,5 mg/kg-1 (grupo S + K), lidocaina 5% 1,5 mg/kg-1 (grupo L5%), adrenalina 15 μg (grupo ADR) y suero fisiologico 3 ml (grupo SF; grupo control). Se evaluaron los …