0000000000353764

AUTHOR

Regina Marquina

showing 2 related works from this author

Identification from a Positional Scanning Peptoid Library of in Vivo Active Compounds That Neutralize Bacterial Endotoxins

2005

4 pages, 3 figures, 1 table.-- PMID: 15715495 [PubMed].-- Printed version published Feb 24, 2005.-- Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jm040834i

LipopolysaccharidesGram-negative bacteriaDatabases FactualLipopolysaccharideStereochemistryLipopolysaccharide (LPS)Peptidemedicine.disease_causeLipid AMiceVivo active compoundsPeptoidschemistry.chemical_compoundIn vivoGram-Negative BacteriaDrug DiscoverymedicineAnimalsPositional scanning peptoid libraryPeptide librarychemistry.chemical_classificationbiologyTumor Necrosis Factor-alphaToxinPeptoidbiology.organism_classificationLipid ABiochemistrychemistryMolecular Medicinelipids (amino acids peptides and proteins)Journal of Medicinal Chemistry
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Increased Goodpasture antigen-binding protein expression induces type IV collagen disorganization and deposit of immunoglobulin A in glomerular basem…

2007

Increased expression of Goodpasture antigen-binding protein (GPBP), a protein that binds and phosphorylates basement membrane collagen, has been associated with immune complex-mediated pathogenesis. However, recent reports have questioned this biological function and proposed that GPBP serves as a cytosolic ceramide transporter (CERTL). Thus, the role of GPBP in vivo remains unknown. New Zealand White (NZW) mice are considered healthy animals although they convey a genetic predisposition for immune complex-mediated glomerulonephritis. Here we show that NZW mice developed age-dependent lupus-prone autoimmune response and immune complex-mediated glomerulonephritis characterized by elevated GP…

Immunoglobulin ACollagen Type IVAgingMice Inbred StrainsMice TransgenicAntigen-Antibody ComplexProtein Serine-Threonine Kinasesurologic and male genital diseasesPathology and Forensic MedicinePathogenesisType IV collagenMiceGlomerulonephritisSpecies SpecificityGlomerular Basement MembranemedicineGoodpasture syndromeAnimalsHumansLupus Erythematosus SystemicAutoantibodiesAutoimmune diseaseBasement membranebiologyGlomerular basement membraneGlomerulonephritismedicine.diseaseImmunoglobulin Amedicine.anatomical_structureImmunologyCancer researchbiology.proteinRegular Articles
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