Dynamic formation of hybrid peptidic capsules by chiral self-sorting and self-assembly.
Owing to their versatility and biocompatibility, peptide-based self-assembled structures constitute valuable targets for complex functional designs. It is now shown that artificial capsules based on β-barrel binding motifs can be obtained by means of dynamic covalent chemistry (DCC) and self-assembly. Short peptides (up to tetrapeptides) are reversibly attached to resorcinarene scaffolds. Peptidic capsules are thus selectively formed in either a heterochiral or a homochiral way by simultaneous and spontaneous processes, involving chiral sorting, tautomerization, diastereoselective induction of inherent chirality, and chiral self-assembly. Self-assembly is shown to direct the regioselectivit…
Experiences with applications of macromolecular tools in supramolecular crystallography
Supramolecular structures, with ever increasing size ranging from a few up to tens of nanometres, represent an intermediate stage between small molecules and biological macromolecules. Many crystal structures of these large supramolecular assemblies have been solved using dual space algorithms. However, supramolecular assemblies with a capsular shape present a particular challenge for crystallography, especially when they are chiral and composed of only light atoms. In this paper, we show that the application of “routine” macromolecular tools may be of great help in solving the crystal structures of supramolecular assemblies that are otherwise refractory to the routine methods of small mole…
CCDC 971033: Experimental Crystal Structure Determination
Related Article: Michał Wierzbicki, Mirosław Gilski, Kari Rissanen, Mariusz Jaskólski, Agnieszka Szumna|2014|CrystEngComm|16|3773|doi:10.1039/C3CE42288G
CCDC 1006725: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 1006724: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 1006726: Experimental Crystal Structure Determination
Related Article: Hanna Jędrzejewska, Michał Wierzbicki, Piotr Cmoch, Kari Rissanen, Agnieszka Szumna|2014|Angew.Chem.,Int.Ed.|53|13760|doi:10.1002/anie.201407802
CCDC 971032: Experimental Crystal Structure Determination
Related Article: Michał Wierzbicki, Mirosław Gilski, Kari Rissanen, Mariusz Jaskólski, Agnieszka Szumna|2014|CrystEngComm|16|3773|doi:10.1039/C3CE42288G