Farmaco-resistenza in stipiti di Helicobacter pylori isolati da pazienti afferenti a strutture ospedaliere della Sicilia centro-occidentale.

2010

Resistance to clarithromycin and genotypes in Helicobacter pylori strains isolated in Sicily

2015

The resistance of Helicobacter pylori strains to clarithromycin is increasing in several developed countries and their association with a genetic pattern circulation has been variously explained as related to different geographical areas. In this study we have reported: the prevalence of the resistance of H. pylori, isolated in Sicily, to clarithromycin; the principal point of mutation associated with this resistance; and the more frequent association between resistance to clarithromycin and cagA, the EPIYA motif, and the vacA and oipA genes. Resistance to clarithromycin was detected in 25 % of cases, the main genetic mutation involved being A2143G. The cagA gene was present in 48 % of case…