0000000000362267

AUTHOR

Cristóbal Aguilar

showing 3 related works from this author

Assessment of immunodeficiency scoring index performance in enterovirus/rhinovirus respiratory infection after allogeneic hematopoietic stem cell tra…

2020

BACKGROUND: Enterovirus/rhinoviruses (EvRh) are the most common cause of respiratory virus infections in recipients of allogeneic stem cell transplantation (allo-HSCT).; OBJECTIVE: We sought to analyze the value of the immunodeficiency scoring index (ISI) in predicting lower respiratory tract disease (LRTD) progression and mortality in a prospective cohort of consecutive adult (> 16 years) allo-HSCT recipients with EvRh infection from December 1 2013 to December 1 2019 at two Spanish transplant centers.; RESULTS: We included 234 allo-HSCT recipients with 383 EvRh episodes. Out of 383 EvRh episodes, 98 (25%) had LRTD. Multivariate logistic regression analysis identified three independent fac…

AdultMalemedicine.medical_specialtyAdolescentRhinovirusmedicine.medical_treatmentHematopoietic stem cell transplantationcommunity acquired respiratory virus030230 surgerymedicine.disease_cause03 medical and health sciencesYoung Adult0302 clinical medicineInternal medicineallogeneic stem celltrasplantationmedicineHumansTransplantation HomologousProspective StudiesProspective cohort studyRespiratory Tract InfectionsImmunodeficiencyimmunodeficiency scoring indexAgedRetrospective StudiesTransplantationPicornaviridae InfectionsRespiratory tract infectionsbusiness.industryHematopoietic Stem Cell TransplantationImmunologic Deficiency SyndromesRespiratory infectionMiddle Agedmedicine.diseaseTransplantationInfectious DiseasesrhinovirusROC CurveSpainMultivariate AnalysisRespiratory virus030211 gastroenterology & hepatologyFemaleRhinovirusbusiness
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Functional Genomics of 5-to 8-Cell Stage Human Embryos by Blastomere Single-Cell cDNA Analysis

2010

Blastomere fate and embryonic genome activation (EGA) during human embryonic development are unsolved areas of high scientific and clinical interest. Forty-nine blastomeres from 5- to 8-cell human embryos have been investigated following an efficient single-cell cDNA amplification protocol to provide a template for high-density microarray analysis. The previously described markers, characteristic of Inner Cell Mass (ICM) (n = 120), stemness (n = 190) and Trophectoderm (TE) (n = 45), were analyzed, and a housekeeping pattern of 46 genes was established. All the human blastomeres from the 5- to 8-cell stage embryo displayed a common gene expression pattern corresponding to ICM markers (e.g., …

BlastomeresDNA ComplementaryScienceCell Biology/Developmental Molecular MechanismsBiologyDevelopmental Biology/Molecular DevelopmentmedicineHumansInner cell massHuman embryogenesisBlastocystCell Biology/Gene ExpressionOligonucleotide Array Sequence AnalysisDevelopmental Biology/EmbryologyMultidisciplinaryMicroarray analysis techniquesGene Expression ProfilingGenetics and Genomics/Functional GenomicsQRGenetics and Genomics/Gene ExpressionEmbryoGenomicsBlastomereGenetics and Genomics/BioinformaticsMolecular biologyEmbryonic stem cellDevelopmental Biology/Stem CellsGene expression profilingmedicine.anatomical_structureembryonic structuresMedicineResearch Article
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Sirolimus versus cyclosporine in haploidentical stem cell transplantation with posttransplant cyclophosphamide and mycophenolate mofetil as graft‐ver…

2021

Sirolimus has emerged as an alternative to calcineurin inhibitors-based (CNI) graft-versus-host disease (GVHD) prophylaxis. This retrospective study compares the outcome of 133 consecutive adult patients with haematological malignancies undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide (PTCy) and mycophenolate mofetil (MMF), combined with cyclosporine A (PTCy-CsA-MMF,

medicine.medical_specialtyHaploidentical transplantationCyclophosphamidebusiness.industryUrologyMycophenolatemedicine.diseaseTransplantationGraft-versus-host diseaseSirolimusToxicityMedicineStem cellbusinessmedicine.drugeJHaem
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