0000000000367295

AUTHOR

Maria Laura Ponti

showing 2 related works from this author

Treatment of hepatitis C virus infection with direct-acting antiviral drugs is safe and effective in patients with hemoglobinopathies

2017

Progression of liver fibrosis in patients with hemoglobinopathies is strongly related to the severity of iron overload and the presence of chronic hepatitis C virus (HCV) infection. Effective iron chelation therapy and HCV infection eradication may prevent liver complications. The European Association for the Study of the Liver guidelines recommend interferon-free regimens for the treatment of HCV infection in patients with hemoglobinopathies. However, data regarding the use of direct-acting antiviral drugs (DAAs) in this patient population are few. This observational study evaluated the safety and efficacy of therapy with DAAs in an Italian cohort of patients with hemoglobinopathies, chron…

Liver CirrhosisAdultMalemedicine.medical_specialtyIron OverloadThalassemiaHepatitis C virusLiver CirrhosiIron Chelating Agentsmedicine.disease_causeAntiviral AgentsGastroenterologyVirus03 medical and health sciencesLiver disease0302 clinical medicineInternal medicinemedicinechronic hepatitis CHumansHematology hemoglobinopathies chronic hepatitis C direct antiviral agentsChelation therapyChronicAntiviral AgentSettore MED/12 - GastroenterologiaHematologybusiness.industrydirect antiviral agentsAdult; Antiviral Agents; Female; Hemoglobinopathies; Hepatitis C Chronic; Humans; Iron Chelating Agents; Iron Overload; Liver Cirrhosis; Male; Middle Aged; Treatment Outcome; HematologyHepatitis CHematologyHepatitis C ChronicMiddle Agedmedicine.diseaseHepatitis CHemoglobinopathiesHemoglobinopathieIron Chelating AgentTreatment Outcome030220 oncology & carcinogenesisImmunologyCohort030211 gastroenterology & hepatologyFemalebusinessHuman
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Frequent NS5A and multiclass resistance in almost all HCV genotypes at DAA failures: What are the chances for second-line regimens?

2017

0301 basic medicinemedicine.medical_specialtyhepacivirusHCV RASTreatment outcomeDrug ResistanceHCV genotypesDrug resistanceBiologyNS5A03 medical and health sciences0302 clinical medicineSecond linedrug resistance viral; humans; retreatment; treatment outcome; antiviral agents; hepacivirus; hepatitis c chronicInternal medicineDrug Resistance Viral; Humans; Retreatment; Treatment Outcome; Antiviral Agents; Hepacivirus; Hepatitis C ChronicDrug Resistance Viralantiviral agentsmedicineViralChronicNS5AhumansHepatologyhepatitis c chronicHepatitis CHepatitis C ChronicSettore MED/07 - Microbiologia e Microbiologia Clinicamedicine.diseaseHepatitis CVirologyHepatology HCV NS5A030104 developmental biologyHCVtreatment outcome030211 gastroenterology & hepatologyretreatmentdrug resistance viral
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