0000000000369919
AUTHOR
Schillaci Domenico
E se il punteruolo affamasse Steinernema carpocapsae?
Rhynchophorus ferrugineus (Olivier 1790) (Coleoptera: Curculionidae), phytophagus of palms, has been used as a model to deepen the knowledge of the host-entomopathogen relationship. The effects of Steinernema carpocapsae (Nematoda: Steinernematidae) on the growth and immunoactivity of R. ferrugineus larvae were compared with another model insect Galleria mellonella L. (Lepidoptera: Pyralidae). Although S. carpocapsae had a negative effect on the weight and mortality of R. ferrugineus, it was not able to replicate in the hemolymph with the same rates found for the moth. In vivo and in vitro effects of S. carpocapsae on the phagocytic responsesof the hemocytes of R. ferrugineus and G. mellone…
Urban Innovation Through Co-design Scenarios. Lessons from Palermo
This paper aims to contribute to current research on learning through designing for urban innovation. It provides a framework methodology for a multidisciplinary ecosystem as a participatory method developed in the context of Mobility Urban Values (MUV), an EU Horizon 2020 project (2017–2020), that addresses the issue of behavioral change towards (more) sustainable mobility lifestyle in EU cities. The paper frames the MUV method through the combination of theories on collaborative urban planning and participatory design with a background rooted on governance of public participation, as the interplay between co-creation (thick participation) and co-design (thin participation). MUV participat…
Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones
In order to study the influence of 3-substitution on the cytotoxic activity of 2-styrylquinazolinones, new 6-chloro-2-styryl-3-(heteroaryl)-4(3H)-quinazolinones were synthesized by refluxing equimolar amounts of 6-chloro-2-methyl-3-(heteroaryl)-4(3H)-quinazolinones and benzaldehyde in glacial acetic acid. At 1 microg ml(-1) concentration, almost all 2-styrylquinazolinones showed some cytotoxic activity against the L1210 and K562 leukemia cell lines. However, only 6-chloro-2-styryl-3-(pyrimidin-2yl)-4(3H)-quinazolinone inhibited the growth of these cells by over 50%. This last compound was also the only member of the series that inhibited tubulin polymerization, with an IC(50) value of 5.8 v…
Near-infrared light-responsive and antibacterial injectable hydrogels with antioxidant activity based on a Dopamine-functionalized Gellan Gum for wound healing
The development of wound dressings with combined antioxidant, antibacterial and tissue adhesion functions has been a difficult medical task for the treatment of wound infections. We synthetized a dopamine and PEG functionalized Gellan Gum (GG) to produce an injectable hydrogel with radical scavenging activity having both specific and aspecific antibiotic/antimicrobial properties. Using starting GG with different molecular weights, we obtained two derivatives that have been used to prepare the gel precursor dispersion, that undergoes gelation in the presence of colistin and dried microparticles (MPs) functionalized on the surface with polydopamine (pDA). Both were used to dope the hydrogel, …
Cartoline da Palermo
Con migliaia di anni di storia alle spalle, una straordinaria complessità culturale e una posizione geografica all’esatto confine fra il nord e il sud del mondo, la Sicilia è il perfetto laboratorio per iniziative di innovazione sociale e ambientale. Palermo, in particolare, è un luogo urbano adatto a sperimentare modelli diversi, nuove tecnologie e soluzioni, in condizioni molto simili a quel 80% di città del pianeta che non possono permettersi di riprogettare o trasformare rapidamente il proprio tessuto sociale e urbano. Il contributo offre una panoramica sul percorso del laboratorio PUSH nell'ambito del design per l'innovazione sociale e la sostenibilità a Palermo ed espone l'approccio "…