Author: Virginie Barbet

0000000000372761

AUTHOR

Virginie Barbet

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Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.

2021

International audience; Background : Bisphenol S is an endocrine disruptor exhibiting metabolic disturbances, especially following perinatal exposures. To date, no data are available on the obesogen effects of BPS in a mutligenerational issue.Objectives : We investigated obesogen effects of BPS in a multigenerational study by focusing on body weight, adipose tissue and plasma parameters in male and female mice.Methods : Pregnant C57BL6/J mice were exposed to BPS (1.5 μg/kg bw/day ie a human equivalent dose of 0.12 μg/kg bw/day) by drinking water from gestational day 0 to post natal day 21. All offsprings were fed with a high fat diet during 15 weeks. Body weight was monitored weekly and fat…

medicine.medical_specialty010504 meteorology & atmospheric sciences[SDV]Life Sciences [q-bio]Health Toxicology and MutagenesisAdipose tissue010501 environmental sciencesToxicologyDiet High-Fat01 natural scienceschemistry.chemical_compoundMiceNEFAPhenolsPregnancyLow dose exposureInternal medicinemedicineLipolysisAnimalsObesogenSulfonesPeri-natal exposure0105 earth and related environmental sciences2. Zero hungerTriglyceridebusiness.industryGeneral Medicinemedicine.diseasePollutionEndocrinologyTransgenerational effectschemistryEndocrine disruptorPrenatal Exposure Delayed EffectsLipogenesisFemalebusinessDyslipidemiaObesogenEnvironmental pollution (Barking, Essex : 1987)

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