0000000000374247

AUTHOR

Pierangelo Clerici

showing 2 related works from this author

Evaluation of humoral and cellular response to four vaccines against COVID-19 in different age groups: A longitudinal study

2022

To date there has been limited head-to-head evaluation of immune responses to different types of COVID-19 vaccines. A real-world population-based longitudinal study was designed with the aim to define the magnitude and duration of immunity induced by each of four different COVID-19 vaccines available in Italy at the time of this study. Overall, 2497 individuals were enrolled at time of their first vaccination (T0). Vaccine-specific antibody responses induced over time by Comirnaty, Spikevax, Vaxzevria, Janssen Ad26.COV2.S and heterologous vaccination were compared up to six months after immunization. On a subset of Comirnaty vaccinees, serology data were correlated with the ability to neutr…

COVID-19 VaccinesAd26COVS1vaccines.SARS-CoV-2ImmunologyCOVID-19serologyViral VaccinesvaccinesHumansB-cell memory; COVID-19; cell-mediated immunity; serology; vaccinescell-mediated immunityImmunology and AllergyB-CELL MEMORY COVID-19 CELL-MEDIATED IMMUNITY SEROLOGY VACCINESB-cell memoryLongitudinal StudiesB-cell memory; COVID-19; cell-mediated immunity; serology; vaccines; Humans; Aged; COVID-19 Vaccines; Longitudinal Studies; Ad26COVS1; SARS-CoV-2; COVID-19; Viral VaccinesAgedFrontiers in Immunology
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Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli

2018

Abstract Objective To develop a risk-scoring tool to predict multidrug-resistant (MDR) etiology in patients with bloodstream infections (BSI) caused by Gram-negative bacilli (GNB). Methods A prospective multicenter study analyzed patients with BSI hospitalized in 31 Internal Medicine wards in Italy from March 2012 to December 2012. Patients with BSI caused by MDR-GNB (non-susceptible to at least one agent in three antimicrobial categories) were compared to those with BSI due to susceptible GNB. A logistic regression to identify predictive factors of MDR-GNB was performed and the odds ratio (OR) were calculated. A score to predict the risk of MDR was developed. Results Of 533 BSI episodes, 2…

Male0301 basic medicineMultivariate analysisGram-negative bacilliHospitalized patientsLogistic regressionLikelihood ratios in diagnostic testingRisk FactorsDrug Resistance Multiple BacterialMedicineAge FactorMultidrug-resistantProspective StudiesMultivariate AnalysiAged 80 and overAge FactorsAnti-Bacterial AgentsHospitalizationItalyBloodstream infections; Gram-negative bacilli; Multidrug-resistantBloodstream infections; Gram-negative bacilli; Multidrug-resistant; Internal MedicineFemaleSettore SECS-S/01 - StatisticaHumanmedicine.medical_specialtyLogistic Model030106 microbiologyBloodstream infection03 medical and health sciencesInternal medicineAnti-Bacterial AgentGram-Negative BacteriaGram-Negative Bacterial InfectionInternal MedicineHumansAgedbusiness.industryRisk FactorGram negative bacilliOdds ratiomedicine.diseaseProspective StudieLogistic ModelsROC CurveBlood CultureBacteremiaMultivariate AnalysisEtiologyBloodstream infectionsGram-Negative Bacterial Infectionsbusiness
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