A New Adaptive Neural Harmonic Compensator for Inverter Fed Distributed Generation

This paper deals with the command of inverters in DG (distributed generation) systems by use of linear neural networks in such a way that, with a slight upgrade of their control software, they can be used also to compensate for the harmonic distortion in the node where they are connected (local compensation), that is in the in the point of common coupling (PCC). To this purpose a neural estimator based on linear neurons (ADALINEs) has been developed which is able to act as a selective noise cancellers for each harmonic of the node voltage. The use of linear neurons permits the drawbacks of classical neural networks to be overcome and moreover the neural estimator is easy to implement, thus …

Colon cancer cell-derived exosomes modulate macrophage immunosuppressive phenotype associated to PD-L1 expression

Power Maximization of a PV-Wind HRES via DC-link Voltage Boosting

This paper describes a method for the optimization of a Hybrid Renewable Energy System applied to a low power Photovoltaic-Wind plant. This approach exploits the DC link with a voltage higher than the correspondent value of the batteries, thanks to a suitable DC/DC converter. The goodness of the methodology is firstly proved by means of a novel graphical technique and then verified through numerical simulations. The results are discussed and show that, adopting the proposed technique, a significant increase of the generated power and of the annual energy produced can be achieved.

The use of Genetic Algorithms to solve the allocation problems in the Life Cycle Assessment

The paper applies a GA (Genetic Algorithms) to a multi-output productive process of essential oils, natural and concen-trated juices from oranges and lemonsThe results obtained for the case study taken into consideration showed that the application of GA allows to respect the energ y and mass balances for the examined system .

COLON CANCER CELL-DERIVED EXOSOMES INDUCE MACROPHAGES TO ACQUIRE AN IMMUNOSUPPRESSIVE PHENOTYPE BY UPREGULATING PD-L1 EXPRESSION

Tumor-associated macrophages (TAMs) are a prominent component of cancer microenvironment having a key role in promoting tumor progression. Several studies have demonstrated that TAMs phenotypically and functionally correspond to M2-polarized macrophages thus they exert immunosuppressive functions also associated to the expression of programmed cell death ligand 1 (PD-L1). Within the local tumor microenvironment, tumor-derived exosomes (TDEs) are well known to play a key role in modulating the properties and the behavior of surrounding cells such as TAMs. Even if several studies demonstrated the ability of TDEs to induce M2-like macrophage polarization, few data are available about their inv…

Caveolin-1, breast cancer and ionizing radiation

Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contras…

Exosomes analysis in Non Small Cell Lung Cancer: from in vitro models to preclinical application

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing osteoclasts and bone-forming osteoblasts activity is lost in bone metastasis, inducing osteoclastogenesis. In NSCLC, the epidermal growth factor receptor (EGFR) pathway is constitutively activated. EGFR binds Amphiregulin (AREG) that is overexpressed in several cancers such as colon, breast and lung. Its levels in plasma of NSCLC patients correlate with poor prognosis and AREG was recently found as…