0000000000375452
AUTHOR
S. Bagnulo
TUMORI a CELLULE GERMINALIin ETA' PEDIATRICA: FATTORI PROGNOSTICI del PROTOCOLLO AIEOP TCG 91.
CIRCA IL 20% DEI PAZIENTI CON TUMORI A CELLULE GERMINALI (tcg) SONO RESISTENTI AL TRATTAMENTO. GLI aUTORI HANNO EFFETTUATO UNO STUDIO POLICENTRICO AL FINE DI RILEVARE CORRELAZIONI TRA PARAMETRI CLINOCO/LABORATORISTICI E LA PROGNOSI
GERM CELL TUMOURS IN CHILDREN- A Report of 84 Cases
In January 1991 a Protocol for diagnosis and treatment of Germ Cell Tumours (GCT) in children was activated in 15 Italian Paediatric Centres.
Malignant germ cell tumors in childhood: results of the first Italian cooperative study "TCG 91".
Background and Aims About 20% of patients with germ cell tumor (GCT) are still resistant to therapy. To investigate which features are present in resistant patients, a multicenter study on GCT in children was undertaken to correlate clinical and laboratory parameters with the outcome. Methods Patients aged less than 16 years, with histologically proven extracranial GCT were included. Results Ninety-five patients (median age 33 months, 45 males) were eligible. The site of the primary tumor was gonadal in 59, extragonadal in 36. The stage was I in 39; II in 5; IIIa (microscopic residue) in 7; IIIb (macroscopic residue) in 16; IIIc (unresectable) in 13; IV in 15. The treatment was surgery alon…
MALIGNANT NON-SEMINOMATOUS GERM CELL TUMORS (MNSGCT) IN CHILDREN: Results of a Study of Italian Association Pediatric Oncology (AIEOP).
The authors report the results of the Italian study on the treatment of non-seminomatous germ cell tumors in pediatric age and present the results of the diagnostic and therapeutic process in their experience
GERM CELL TUMOURS: A Report of 72 Cases
The Authours report a prospective Study of the diagnosis and treatment of Germ Cell Tumours in children since January 1991.
Leukemic ophthalmopathy: a report of 21 pediatric cases.
A multicentric retrospective study on leukemic ophthalmopathy (LO) is reported. It includes 21 patients, 16 males and 5 females, with acute leukemia (AL) observed in 10 SIOP centers. LO developed in three patients at the time of diagnosis of AL; five patients were in first complete remission (three off therapy); four patients were in second or third remission; and nine were in combined relapse. Most frequent symptoms were blurred vision, photophobia, and ocular pain. Two patients with acute nonlymphoblastic leukemia died before treatment; another underwent bone marrow transplantation; one patient with B-cell acute lymphoblastic leukemia (B-ALL) treated with chemotherapy and radiotherapy die…