Author: Andreea Bodoki

Oxidative DNA cleavage by copper ternary complexes of 1,10-phenanthroline and ethylenediamine-sulfonamide derivatives

2009

Abstract Ternary copper(II) complexes (1–3) of 1,10-phenanthroline and ethylenediamine-R-sulfonamide derivatives (R = benzene, toluene and naphthalene rings) have been synthesized and characterized with the aid of X-ray diffraction and spectroscopic and electrochemical techniques. The crystal structures of the complexes show that the coordination polyhedron around copper(II) is distorted square planar. Both 1,10-phenanthroline and ethylenediamine-R-sulfonamide act as bidentate ligands. The three structures are stabilized by π–π stacking interactions. The interaction of the complexes with calf thymus DNA has been investigated by thermal denaturation studies which indicated that DNA was stabi…

DNA damageReducing agentPhenanthrolinechemistry.chemical_elementEthylenediamineCleavage (embryo)PhotochemistryCopperInorganic Chemistrychemistry.chemical_compoundchemistryPolymer chemistryMaterials ChemistryHydroxyl radicalPhysical and Theoretical ChemistryDNAPolyhedron

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Synthesis, crystallographic and spectroscopic characterization and magnetic properties of dimer and monomer ternary copper(II) complexes with sulfona…

2010

Abstract Three dinuclear and one mononuclear copper(II)-1,10-phenanthroline ternary complexes, [Cu(L1)(phen)(OH)]2 (1), [Cu(L2)(phen)(OH)]2·3H2O (2), [Cu(L3)(phen)(OH)]2 (3) and [Cu(L4)2(phen)(H2O)] (4), with thiadiazole sulfonamide derivative ligands: HL1 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)naphthalene-1-sulfonamide), HL2 (N-(5-ethylthio)-1,3,4-thiadiazol-2-yl)-4-methylbenzenesulfonamide), HL3 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide) and HL4 (N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-methylbenzenesulfonamide) have been synthesized and characterized. In the four complexes each copper atom is five-coordinated. The structure of complexes 1, 2 and 3 consists of a dimeric unit with a C2 sy…

chemistry.chemical_classificationPhenanthrolineDimerchemistry.chemical_elementCleavage (embryo)Ascorbic acidCopperSulfonamideInorganic Chemistrychemistry.chemical_compoundCrystallographyMonomerchemistryMaterials ChemistryHydroxyl radicalPhysical and Theoretical ChemistryPolyhedron

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New sulfonamide complexes with essential metal ions [Cu (II), Co (II), Ni (II) and Zn (II)]. Effect of the geometry and the metal ion on DNA binding …

2019

Abstract Mixed divalent Cu, Co, Ni and Zn complexes containing the new sulfonamide ligand N–(2–(pyridin–2–yl)ethyl)quinoline–8–sulfonamide (HQSEP) were prepared and characterized by physico-chemical techniques. The tetracoordinate [Cu(QSEP)X] [X = Br (1), Cl (2)] compounds present a seesaw geometry (τ4 = 0.56 (1) and 0.50 (2)). The Cu(II) in the [Cu(QSEP)(NO3)(MeOH)] (3) complex is five coordinate with a slightly distorted SP geometry (τ = 0.11). The [M(QSEP)(benz)] [M = Cu(II) (4), Ni(II) (5), Co(II) (6) and Zn(II) (7); benz = benzoate] compounds are configurationally isotypic. The coordination geometries of the M(II) ions can be best described as distorted SP (τ = 0.29, 0.15, 0.34 and 0.1…

Reaction mechanismMetal ions in aqueous solutionGeometry010402 general chemistry01 natural sciencesBiochemistryDivalentInorganic ChemistryMetalBovine serum albuminDNA Cleavagechemistry.chemical_classificationSulfonamidesDeoxyribonucleasesTetracoordinatebiology010405 organic chemistryChemistryLigandSerum Albumin BovineDNA0104 chemical sciencesSulfonamideMetalsvisual_artvisual_art.visual_art_mediumbiology.proteinJournal of inorganic biochemistry

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Spectroscopic, magnetic, and electrochemical studies of a dimeric N-substituted-sulfanilamide copper(II) complex. X-ray and molecular structure of th…

2010

Abstract A dinuclear copper(II) complex with a N-substituted sulfonamide as ligand has been investigated. The new N-(pyridin-2-yl)biphenyl-4-sulfonamide ligand has been prepared and structurally characterized. The copper(II) complex has been synthesized and its crystal structure, magnetic properties and EPR spectra were studied in detail. The metal centers are bridged by four nonlinear triatomic NCN groups. The coordination geometry of the copper(II) ions in the dinuclear entity is distorted square planar with two N-pyridyl and two N-sulfonamido atoms. Magnetic susceptibility data show a moderate antiferromagnetic coupling, with −2 J = 284 cm−1. The EPR spectrum of the polycrystalline sampl…

LigandTriatomic moleculechemistry.chemical_elementCrystal structurePhotochemistryCopperMagnetic susceptibilitylaw.inventionInorganic ChemistryCrystallographychemistrylawMaterials ChemistryMoleculePhysical and Theoretical ChemistryElectron paramagnetic resonanceCoordination geometryInorganica Chimica Acta

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