0000000000377103

AUTHOR

P. G. Knapstein

showing 3 related works from this author

Ein neues Konzept zur Behandlung von Beckenwandrezidiven gynäkologischer Malignome

1991

Beckenwandrezidive gynakologischer Krebserkrankungen haben eine sehr schlechte Prognose, obwohl etwa die Halfte der Patientinnen geheilt werden konnte, wenn eine lokale Sanierung erreicht wurde. Aus tumor- und strahlenbiologischen Uberlegungen haben wir fur Patientinnen mit unilateralen Beckenwandrezidiven ein neues kombiniertes operatives und strahlentherapeutisches (CORT) Behandlungskonzept entwickelt, das seit 1989 in unserer Klinik angewandt wird. Die Grundlagen und Aspekte der Durchfuhrung des CORT-Konzep-tes haben wir kurzlich veroffentlicht (Hockel et al. 1989).

researchProduct

Effects of interferon gamma on the proliferation and modulation of cell-surface structures of human ovarian carcinoma cell lines.

1993

Platinum-containing regimens are very effective in the primary treatment of ovarian cancer. However, upon subsequent treatment most tumors develop multidrug resistance. The clinical application of biological response modifiers like interferon gamma (IFN gamma) in advanced ovarian cancer is therefore of increasing interest. Permanent ovarian cancer cell lines are suitable for investigating the mode of action and the potential clinical effectiveness of such response modifiers. IFN gamma is known to modulate many cellular functions. In this study it was compared for its antiproliferative and antigen-modulatory activity on the expression of tumor-associated (CA-125, HMFG, CEA) and major histoco…

Cancer ResearchReceptor expressionCellInterferon-gammaAntigenEpidermal growth factorAntigens NeoplasmHLA AntigensMHC class ImedicineTumor Cells CulturedHumansAntigens Tumor-Associated CarbohydrateOvarian NeoplasmsMHC class IIbiologyCell growthCell MembraneGeneral Medicinemedicine.diseaseRecombinant ProteinsErbB ReceptorsGene Expression Regulation Neoplasticmedicine.anatomical_structureOncologyImmunologyAntigens Surfacebiology.proteinCancer researchFemaleOvarian cancerCell DivisionJournal of cancer research and clinical oncology
researchProduct

Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

1991

Cancer Researchmedicine.medical_specialtyOncologybusiness.industrymedicineGeneral MedicineDrug resistancePharmacologyIntensive care medicinebusinessJournal of Cancer Research and Clinical Oncology
researchProduct