0000000000379263
AUTHOR
Ian Smith
Exploring Broadband GRB Behavior During gamma-ray Emission
The robotic ROTSE-III telescope network detected prompt optical emission contemporaneous with the gamma-ray emission of Swift events GRB051109A and GRB051111. Both datasets have continuous coverage at high signal-to-noise levels from the prompt phase onwards, thus the early observations are readily compared to the Swift XRT and BAT high energy detections. In both cases, the optical afterglow is established, declining steadily during the prompt emission. For GRB051111, there is evidence of an excess optical component during the prompt emission. The component is consistent with the flux spectrally extrapolated from the gamma-rays, using the gamma-ray spectral index. A compilation of spectral …
Patient Preferences for Lung Cancer Treatment: A Qualitative Study Protocol Among Advanced Lung Cancer Patients
Introduction: Lung cancer is the deadliest and most prevalent cancer worldwide. Lung cancer treatments have different characteristics and are associated with a range of benefits and side effects for patients. Such differences may raise uncertainty among drug developers, regulators, payers, and clinicians regarding the value of these treatment effects to patients. The value of conducting patient preference studies (using qualitative and/or quantitative methods) for benefits and side effects of different treatment options has been recognized by healthcare stakeholders, such as drug developers, regulators, health technology assessment bodies, and clinicians. However, evidence-based guidelines …
Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and …