0000000000381993
AUTHOR
S Wagner
Laparoscopic versus open retropubic intrafascial nerve-sparing radical prostatectomy: surgical and functional outcomes in 300 patients
Efficacy and tolerance of a medication switch from Escitalopram to Venlafaxine in patients with Major Depressive Disorders
Intercalated cells as a probable source for the development of renal oncocytoma
Renal oncocytoma is a distinct type of epithelial tumor said to arise from the collecting duct system. Here we show that in nine of ten oncocytomas the tumor cells expressed an analog of the erythrocyte anion exchanger band 3. In the normal kidney band 3 is confined to the basolateral surface of the majority of intercalated cells which comprise up to 50% of the cortical collecting duct epithelium. Carbonic anhydrase c is another protein abundant in intercalated cells, and this was also expressed in six of the ten oncocytomas investigated. Immunoreactivity specific for band 3 and carbonic anhydrase c was not detected in any of the 20 renal cell carcinomas examined. At favourable section plan…