Polyamino Acid Carriers In Drug Delivery And Their Production Under Good Manufacturing Practice Compliance

Poly(Amino Acids) (PAA)s are biocompatible, biodegradable and multifunctional polymers, which have been effectively used as building blocks in polymer-based delivery carriers for various medical applications. In addition, PAAs are envisaged to achieve a major impact on biomedical areas due to their structural versatility, biocompatibility, water-solubility and the important advances made on the synthetic strategies. Control on polymer chain length and stereochemistry have been one of the major challenges in PAA synthesis over the past years. Their physico-chemical properties can be modulated in terms of the manufacturing process, size, electrostatic charge, conformation, geometry, topology,…