0000000000384919

AUTHOR

G. Antonelli

showing 3 related works from this author

Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms

2019

AbstractAneurysms and dissections affecting thoracic aorta are associated with smooth muscle cell (SMC) dysfunction. NO/cGMP signaling pathway in smooth muscle cells has been shown to be affected in sporadic thoracic aortic aneurysms. We analyzed the mRNA levels of PDE5, a cGMP-hydrolyzing enzyme highly expressed in aortic SMCs, that regulates arterious vascular tone by lowering cGMP levels. We found that aortic tissue obtained from Marfan, tricuspid and bicuspid thoracic aneurysms expressed lower levels of PDE5 mRNA compared to control aortas. In particular, we found that affected aortas showed lower levels of all the PDE5A isoforms, compared to control aortas. Transfection of vascular SMC…

0301 basic medicineMaleCelllcsh:MedicineStimulationMuscle Smooth VascularAortic aneurysmchemistry.chemical_compound0302 clinical medicinePDE5 expression human aorta and thoracic aortic aneurysmsMyocyteThoracic aortalcsh:ScienceSettore BIO/16MultidisciplinaryTransfectionMiddle AgedIsoenzymesmedicine.anatomical_structurecardiovascular systemFemaleGene isoformAdultmedicine.medical_specialtyMyocytes Smooth MuscleArticleGene Expression Regulation EnzymologicNitric oxide03 medical and health sciencesmedicine.arteryInternal medicinemedicineHumansSettore MED/05 - Patologia ClinicaAgedCyclic Nucleotide Phosphodiesterases Type 5Aortic Aneurysm Thoracicbusiness.industrylcsh:Rmedicine.disease030104 developmental biologyEndocrinologychemistryRisk factorsthoracic aortic aneurysmslcsh:QAngiogenesisPDE5business030217 neurology & neurosurgery
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The THYCOVIT (Thyroid Surgery during COVID-19 pandemic in Italy) study: results from a nationwide, multicentric, case-controlled study

2021

AbstractThe outbreak of the COVID-19 pandemic has led to a disruption of surgical care. The aim of this multi-centric, retrospective study was to evaluate the impact of the pandemic on surgical activity for thyroid disease among the Italian Units of Endocrine Surgery. Three phases of the pandemic were identified based on the epidemiological situation and the public measures adopted from the Italian Government (1st phase: from 9th March to 3rd May 2020; 2nd phase: from 4th May to 14th June; 3rd phase: from 15th June to 31st). The patients operated upon during these phases were compared to those who underwent surgery during the same period of the previous year. Overall, 3892 patients from 28 …

COVID-19; Endocrine surgery; SARS-CoV-2; Thyroid carcinoma; Thyroidectomymedicine.medical_specialtymedicine.medical_treatmentThyroid GlandCOVID-19; Endocrine surgery; SARS-CoV-2; Thyroid carcinoma; Thyroidectomy; Humans; Italy; Retrospective Studies; SARS-CoV-2; COVID-19; Pandemics; Thyroid GlandNOThyroid carcinomaRetrospective StudiePandemicEpidemiologymedicineHumansThyroid cancerPandemicsLS7_4Retrospective StudiesPandemicbusiness.industrySARS-CoV-2Thyroid diseaseThyroidectomyCase-control studyCOVID-19Retrospective cohort studymedicine.diseaseSurgeryEndocrine surgeryEndocrine surgeryItalyThyroidectomyOriginal ArticleSurgerybusinessHuman
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Impact of the COVID-19 pandemic on surgery for thyroid cancer in Italy: nationwide retrospective study

2021

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2019-20 coronavirus outbreakmedicine.medical_specialtyAcademicSubjects/MED00910Coronavirus disease 2019 (COVID-19)medicine.medical_treatmentSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)pandemicsNOPandemicResearch LettermedicinehumansThyroid cancerThyroid NeoplasmLS7_4Thyroid Neoplasms; Thyroidectomy; SARS-CoV-2; COVID-19; Pandemics; ItalyPandemicbusiness.industrySARS-CoV-2thyroid neoplasmsThyroidectomyCOVID-19Retrospective cohort studymedicine.diseaseComorbidityCOVID-19; comorbidity; humans; Italy; retrospective studies; SARS-CoV-2; thyroid neoplasms; pandemics; thyroidectomySettore MED/18 - Chirurgia Generalecomorbidityretrospective studiesItalyEmergency medicinethyroidectomyThyroidectomySurgeryAcademicSubjects/MED00010business
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