Author: Cécile Gladine

0000000000387324

AUTHOR

Cécile Gladine

DHA dose-dependently reduces atherosclerosis: a putative role for its peroxidation metabolites, F4-Neuroprostanes

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La teneur hépatique en F4-Neuroprostanes : une variable prédictive majeure de la réduction de la plaque d’athérome

Le fichier annexe contient le livre des résumés; Les propriétés athéroprotectrices des acides gras polyinsaturés de type n-3 à longue chaîne (AGPI n-3 LC), et en particulier de l’acide docosahexaénoique (DHA) ont été largement décrites. Néanmoins, les mécanismes d’action restent encore mal connus. Les recherches se sont récemment orientées vers l’identification des métabolites oxygénés issus des AGPI n-3 LC qui sont de plus en plus considérés comme des effecteurs majeurs de leurs effets athéroprotecteurs. Dans ce contexte, une étude dose-réponse de supplémentation en DHA a été réalisée chez un modèle animal d’athérosclérose (souris LDLR-/-) afin d’étudier les relations entre la progression …

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The paradox of omega 3 PUFAs: autoprotection although highly susceptible to peroxidation

National audience

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Anti-atherogenic action of DHA in LDLR-/- mice: are DHA oxygenated metabolites players in the resolution of inflammation?

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Atheroprotective effects and peroxidation of docosahexaenoic acid: is there a direct link?

International audience

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Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of atherosclerosis prevention

International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…

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