Author: J.w. Newman

0000000000387325

AUTHOR

J.w. Newman

DHA dose-dependently reduces atherosclerosis: a putative role for its peroxidation metabolites, F4-Neuroprostanes

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La teneur hépatique en F4-Neuroprostanes : une variable prédictive majeure de la réduction de la plaque d’athérome

Le fichier annexe contient le livre des résumés; Les propriétés athéroprotectrices des acides gras polyinsaturés de type n-3 à longue chaîne (AGPI n-3 LC), et en particulier de l’acide docosahexaénoique (DHA) ont été largement décrites. Néanmoins, les mécanismes d’action restent encore mal connus. Les recherches se sont récemment orientées vers l’identification des métabolites oxygénés issus des AGPI n-3 LC qui sont de plus en plus considérés comme des effecteurs majeurs de leurs effets athéroprotecteurs. Dans ce contexte, une étude dose-réponse de supplémentation en DHA a été réalisée chez un modèle animal d’athérosclérose (souris LDLR-/-) afin d’étudier les relations entre la progression …

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The paradox of omega 3 PUFAs: autoprotection although highly susceptible to peroxidation

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PEPhysical Sciences and Engineering
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