0000000000392768
AUTHOR
Jean-christophe Helbling
Genetic variability in metabolic and behavioral responses to Western life style: analysis of the transcortin-deficient mouse after high fat diet and chronic stress
National audience
Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits
International audience; Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational impairments. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor-expressing medium spiny neurons (D2-MSNs) onto dopamine D1 receptor-expressing MSNs in the nucleus accumbens, a main brain regio…