0000000000393632
AUTHOR
F. Orestano
Osservational Study on Early Diagnosis of Prostate Carcinoma in Sicily and Calabria
The diagnosis of prostate carcinoma has been monitored in Sicily and Calabria for one year. Material e Methods Twenty-seven urological centres of Sicily and Calabria joined the study. Detailed informations about age, familiarity, PSA, Gleason score and TNM stage at diagnosis were centralized between november 2001 and november 2002. Results 721 patients have been recruited. The median age was 73 years. More than 80% of the patients were older than 65 years. Median PSA was 14 ng/ml. The clinical stage at diagnosis was T1c in 33% of patients and 67% had an organ confined prostate cancer (T1-T2). Familiarity was detected in 8% of cases. Age and PSA at diagnosis in these patients were similar t…
Beeinflussung des Testosteronmetabolismus durch Oestrogene im Prostataadenom- und Carcinomgewebe
Das im Hypophysenvorderlappen entstehende Gonadotropin ICSH stimuliert die Leydigsehen Zellen zur Testosteronproduktion. Die ICSH-Ausschuttung wird durch das Testosteron und moglicherweise auch durch die Oestrogene, welche in geringen Mengen von den Leydigschen Zellen sezerniert werden, gegenreguliert. Testosteron stimuliert das Wachstum und die sekretorische Tatigkeit der Prostata. Das Testosteron wird in der Prostatazelle zu 5 α-Dihydrotestosteron reduziert und dieses wird durch eine 3 keto-Reduktase im Cytoplasma, aber nicht im Nucleus der Zelle, zu Androstandiol metabolisiert.
Open prostatectomy for benign prostatic enlargement in southern Europe in the late 1990s: A contemporary series of 1800 interventions
Abstract Objectives Contemporary series of open prostatectomies from Western countries are rare. Frequently, the analysis of the outcome of open prostatectomy refers to old experiences or to series from developing countries. Any comparison with transurethral resection of the prostate can be invalidated by complications of open surgery because of the lack of an adequate healthcare system and technology. Methods The Sicilian-Calabrian Society of Urology performed a retrospective study to assess the surgical management of benign prostatic hyperplasia in Sicily and Calabria in 1997 and 1998. A three-page questionnaire was sent to the 36 urologic units of these two Italian regions with more than…
Testosterone metabolism in benign prostatic hypertrophy: in vivo studies of gestonorone caproate and cyproterone acetate.
Summary 18 patients with obstructive benign prostatic hypertrophy were studied. A 5-day treatment with gestonorone caproate (200 mg daily and 200 mg on alternate days) and cyproterone acetate (300 mg daily) suppressed the plasma LH and serum LH levels. Subsequently, H3-testosterone was injected intravenously and its elimination from plasma and uptake and metabolism in the BPH tissue studied. The elimination of total radioactivity and H3-testosterone from plasma was not altered after the 3 treatment regimens as compared to the control group. The uptake of total radioactivity into BPH tissue and its intraprostatic metabolism particularly to dihydrotestosterone was significantly suppressed in …
Management of symptomatic benign prostatic hyperplasia in southern Italy: a retrospective analysis of the Sicilian-Calabrian Society of Urology (SSCU) of 32,000 patients.
<i>Introduction:</i> The availability of new pharmacological and surgical options is responsible for important changes in the management of symptomatic benign prostate hyperplasia (BPH). The Sicilian-Calabrian Society of Urology performed a retrospective survey to assess the management of BPH in southern Italy in 1997 and 1998. <i>Patients and Methods:</i> A 3-page questionnaire was sent to the 36 urological units of these two regions. The real number of patients treated was required. The numbers were checked with data obtained from the Health Regional Offices. <i>Results:</i> Twenty-six urological units (72.3%) replied. Almost all patients underwent urin…