0000000000396012

AUTHOR

Thomas Munsch

showing 2 related works from this author

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

1990

0303 health sciencesPhysiologyChemistryClinical BiochemistryTibialis AnteriorHuman physiology030204 cardiovascular system & hematologyPharmacologySpring (mathematics)ArticleAtrial Natriuretic Peptide03 medical and health sciences0302 clinical medicineAtrial natriuretic peptidePhysiology (medical)Spreading DepressionCapsaicinExtensor Digitorum Longus030304 developmental biologyPflugers Archiv
researchProduct

BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion

2014

BDNF and nitric oxide signaling both contribute to plasticity at glutamatergic synapses. However, the role of combined signaling of both pathways at the same synapse is largely unknown. Using NO imaging with diaminofluoresceine in cultured hippocampal neurons we analyzed the time course of neurotrophin-induced NO signals. Application of exogenous BDNF, NT-4, and NT-3 (but not NGF) induced NO signals in the soma and in proximal dendrites of hippocampal neurons that were sensitive to NO synthase activity, TrkB signaling, and intracellular calcium elevation. The effect of NO signaling on neurotrophin secretion was analyzed in BDNF-GFP, and NT-3-GFP transfected hippocampal neurons. Exogenous ap…

Tropomyosin receptor kinase BBiologyHippocampal formationneurotrophinsNitric oxidelcsh:RC321-571SynapseCellular and Molecular Neurosciencechemistry.chemical_compoundnitric oxideOriginal Research Articlelcsh:Neurosciences. Biological psychiatry. Neuropsychiatrypeptide secretionsynaptic plasticityTrkBPSD95DepolarizationPeptide secretionBDNFchemistrynervous systemSynaptic plasticitybiology.proteinNeuroscienceNeurotrophinNeuroscienceFrontiers in Cellular Neuroscience
researchProduct