0000000000398226

AUTHOR

Remedios Guna

showing 4 related works from this author

In vitro activity of linezolid, clarithromycin and moxifloxacin against clinical isolates of Mycobacterium kansasii

2005

To compare the activity of linezolid with a range of drugs used in the treatment of Mycobacterium kansasii infections.The percentages of resistant isolates against isoniazid, rifampicin and ethambutol were 2.9%, 1.9% and 2.9%, respectively. All isolates were susceptible to clarithromycin and moxifloxacin both with MIC(90) values of 0.125 mg/L. Linezolid was active against all isolates with MIC(50) and MIC(90) values of 0.5 and 1 mg/L, respectively, both below the susceptibility breakpoint established for mycobacteria.Linezolid, clarithromycin or moxifloxacin, could be used as alternative drugs for treatment of infections due to rifampicin-resistant isolates as well as short-course or interm…

Microbiology (medical)MoxifloxacinMicrobial Sensitivity TestsBiologyMicrobiologychemistry.chemical_compoundMoxifloxacinClarithromycinClarithromycinAcetamidesDrug Resistance Bacterialpolycyclic compoundsmedicineHumansheterocyclic compoundsPharmacology (medical)OxazolidinonesEthambutolAntibacterial agentPharmacologyMycobacterium kansasiiAza CompoundsIsoniazidLinezolidbiochemical phenomena metabolism and nutritionbacterial infections and mycosesbiology.organism_classificationAnti-Bacterial AgentsInfectious DiseaseschemistryMycobacterium kansasiiLinezolidQuinolinesbacteriaRifampicinFluoroquinolonesmedicine.drugJournal of Antimicrobial Chemotherapy
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Epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole for six Candida species as determined by the colorimetric…

2013

ABSTRACT In the absence of clinical breakpoints (CBP), epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of susceptibility tests. Sensititre YeastOne (SYO) is a widely used method to determine susceptibility of Candida spp. to antifungal agents. The CLSI CBP have been established, but not for the SYO method. The ECVs for four azoles, obtained using MIC distributions determined by the SYO method, were calculated via five methods (three statistical methods and based on the MIC 50 and modal MIC). Respectively, the median ECVs (in mg/lit…

Microbiology (medical)AzolesPosaconazolemedicine.medical_specialtyAntifungal AgentsItraconazoleMycologyMicrobial Sensitivity TestsBiologyMicrobiology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]EpidemiologymedicineHumansCutoffCandida albicansPruebas de sensibilidad microbianaCandidaVoriconazoleCandidiasisLiter:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Azoles [Medical Subject Headings]:Diseases::Bacterial Infections and Mycoses::Mycoses::Candidiasis [Medical Subject Headings]biology.organism_classification:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antifungal Agents [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests [Medical Subject Headings]:Organisms::Eukaryota::Fungi::Mitosporic Fungi::Candida [Medical Subject Headings]AntifúngicosFluconazolemedicine.drug
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New agents active against Mycobacterium avium complex selected by molecular topology: a virtual screening method

2003

Objectives: In order to select new drugs and to predict their in vitro activity against Mycobacterium avium complex (MAC), new quantitative structure-activity relationship (QSAR) models were developed. Methods: The activities against MAC of 29 structurally heterogeneous drugs were examined by means of linear discriminant analysis (LDA) and multilinear regression analysis (MLRA) by using topological indices (TI) as structural descriptors. In vitro antimycobacterial activities were determined by a broth microdilution method with 7H9 medium. Results: The topological model obtained successfully classifies over 80% of compounds as active or inactive; consequently, it was applied in the search fo…

PharmacologyMicrobiology (medical)Virtual screeningQuantitative structure–activity relationshipbiologymedicine.drug_classBroth microdilutionQuantitative Structure-Activity RelationshipMicrobial Sensitivity TestsComputational biologyMycobacterium avium Complexbiology.organism_classificationLinear discriminant analysisAntimycobacterialModels BiologicalIn vitroAnti-Bacterial AgentsMicrobiologyInfectious DiseasesDrug DesignmedicinePharmacology (medical)Mycobacterium avium complexMolecular topologyJournal of Antimicrobial Chemotherapy
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Search of Chemical Scaffolds for Novel Antituberculosis Agents

2005

3 A method to identify chemical scaffolds potentially active against Mycobacterium tuberculosis is presented. The molecular features of a set of structurally heterogeneous antituberculosis drugs were coded by means of structural invariants. Three tech- niques were used to obtain equations able to model the antituberculosis activity: linear discriminant analysis, multilinear re- gression, and shrinkage estimation-ridge regression. The model obtained was statistically validated through leave-n-out test, and an external set and was applied to a database for the search of new active agents. The selected compounds were assayed in vitro, and among those identified as active stand reserpine, N,N,N…

0301 basic medicineStereochemistryAntitubercular AgentsQuantitative Structure-Activity RelationshipComputational biology01 natural sciencesBiochemistryAnalytical ChemistryMycobacterium tuberculosis03 medical and health sciencesmedicineComputer SimulationMycobacterium avium complexEthambutolVirtual screeningMolecular StructurebiologyChemistrybiology.organism_classificationLinear discriminant analysis0104 chemical sciences010404 medicinal & biomolecular chemistry030104 developmental biologyModels ChemicalDrug DesignRegression AnalysisMolecular MedicineMultiple linear regression analysisBiotechnologyPentamidinemedicine.drugSLAS Discovery
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