0000000000400117

AUTHOR

José E. Clar

showing 2 related works from this author

ChemInform Abstract: Trienediolates of Hexadienoic Acids in Synthesis. Synthesis of Retinoic and nor-Retinoic Acids.

2010

Abstract Double deprotonation of either (E,E)-3-methyl-2,4-hexadienoic acid 2, or 4,6-dimethyldihydro-2-pyrone 3 generates apparently the same lithium trienediolate, which affords ω-hydroxy acids 9 on reaction with ketones 7. Hydroxy acids 9 are easily dehydrated to octatrienoic acids 5, which are structurally related to retinoic acid. Similarly, sorbic acid 1 leads to nor-retinoic acid analogs 6.

chemistry.chemical_compoundAddition reactionDeprotonationchemistryRetinoic acidchemistry.chemical_elementLithiumGeneral MedicineSorbic acidMedicinal chemistryChemInform
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Trienediolates of hexadienoic acids in synthesis. synthesis of retinoic and nor-retinoic acids.

1993

Abstract Double deprotonation of either (E,E)-3-methyl-2,4-hexadienoic acid 2, or 4,6-dimethyldihydro-2-pyrone 3 generates apparently the same lithium trienediolate, which affords ω-hydroxy acids 9 on reaction with ketones 7. Hydroxy acids 9 are easily dehydrated to octatrienoic acids 5, which are structurally related to retinoic acid. Similarly, sorbic acid 1 leads to nor-retinoic acid analogs 6.

chemistry.chemical_classificationAddition reactionKetoneChemistryOrganic ChemistryRetinoic acidBiochemistrychemistry.chemical_compoundDeprotonationDrug DiscoveryOrganic chemistryStereoselectivityAliphatic compoundSorbic acidAcetophenoneTetrahedron
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