0000000000400219

AUTHOR

Dagnija Loča

showing 3 related works from this author

Functionalized silver doped hydroxyapatite scaffolds for controlled simultaneous silver ion and drug delivery

2017

Abstract Bacterial infections are a major problem in bone tissue regeneration, thus it is essential to incorporate antibacterial properties within the bone scaffolds. Silver compounds are frequently used as antibacterial agents to prevent bacterial infections and numerous studies have shown that silver ions can be incorporated within the biocompatible and osteoconductive biomaterial hydroxyapatite (HAp) structure, but, so far, no study has thoroughly evaluated silver ion release rates in long term. Therefore, we have established a novel carrier system for local drug delivery based on functionalized silver doped hydroxyapatite with determined long term silver ion release rates. Silver ions f…

Materials scienceCarrier systemProcess Chemistry and TechnologySimulated body fluidBiomaterial02 engineering and technologyLidocaine Hydrochloride010402 general chemistry021001 nanoscience & nanotechnologyBone tissue01 natural sciences0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsChitosanchemistry.chemical_compoundmedicine.anatomical_structurechemistryChemical engineeringDrug deliveryMaterials ChemistryCeramics and Compositesmedicine0210 nano-technologyAntibacterial activityCeramics International
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FACTORS AFFECTING CHINESE HAMSTER OVARY CELL PROLIFERATION AND VIABILITY

2019

Advantageous cultivation procedures for the Chinese hamster ovary (CHO) cells are necessary for the productive commercial production of biopharmaceuticals. A main challenge that needs to be addressed during the process development is the differences in each cell line requirements concerning the nutrients and feed strategies in order to achieve the desired growth characteristics. Therefore, within the current research, a naïve high cell density serum free suspension adapted CHO cell line was tested with glucose and glutamine rich feeds in fed-batch Erlenmeyer shake flask cultures. Glucose consumption rate was adjusted to develop the optimal feed strategies. Obtained results indicated that hi…

GlutamineNutrientErlenmeyer flasklawCell growthChemistryCell cultureChinese hamster ovary cellViability assayFood scienceMaximum Cell Densitybiotechnology; cell proliferation; Chinese hamster ovary cells; feeding strategylaw.inventionENVIRONMENT. TECHNOLOGIES. RESOURCES. Proceedings of the International Scientific and Practical Conference
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VISUALIZATION APPROACHES FOR STIRRED TANK BIOREACTORS

2019

Computational Fluid Dynamics (CFD) is the analysis of fluid behaviour employing numerical solution methods. Using CFD it is possible to analyse simple and complex fluid-gas, fluid-fluid or fluid-solid interactions. Fluid dynamics is described with laws of physics in the form of partial differential equations also known as Navier-Stokes equations. Sophisticated CFD solvers transform these laws into algebraic equations which are solved by numerical methods. In this paper Ansys CFX and Fluent analysis systems as research methods are used to visualize flow patterns in a stirred tank bioreactor. The results obtained are informative and can be used to improve the yield of biomass. CFD analysis ca…

Partial differential equationbusiness.industryComputer scienceTurbulenceComputationNumerical analysisAnsys CFX/Fluent; CFD; bioreactor; stirred tankMechanicsComputational fluid dynamicsPhysics::Fluid DynamicsAlgebraic equationFluid dynamicsFluentbusinessEnvironment. Technology. Resources. Proceedings of the International Scientific and Practical Conference
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