Patisiran Enhances Muscle Mass after Nine Months of Treatment in ATTRv Amyloidosis: A Study with Bioelectrical Impedance Analysis and Handgrip Strength
Background and aims. Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv) is caused by mutations in the TTR gene, leading to misfolded monomers that aggregate generating amyloid fibrils. The clinical phenotype is heterogeneous, characterized by a multisystemic disease affecting the sensorimotor, autonomic functions along with other organs. Patisiran is a small interfering RNA acting as a TTR silencer approved for the treatment of ATTRv. Punctual and detailed instrumental biomarkers are on demand for ATTRv to measure the severity of the disease and monitor progression and response to treatment. Methods. Fifteen patients affected by ATTRv amyloidosis (66.4 ± 7.8 years, six males) …
Match Load Physical Demands in U-19 Professional Soccer Players Assessed by a Wearable Inertial Sensor
Background: Wearable inertial sensors are poorly used in soccer to monitor external load (EL) indicators. However, these devices could be useful for improving sports performance and potentially reducing the risk of injury. The aim of this study was to investigate the EL indicators (i.e., cinematic, mechanical, and metabolic) differences between playing positions (i.e., central backs, external strikers, fullbacks, midfielders, and wide midfielder) during the first half time of four official matches (OMs). Methods: 13 young professional soccer players (Under-19; age: 18.5 ± 0.4 years; height: 177 ± 6 cm; weight: 67 ± 4.8 kg) were monitored through a wearable inertial sens…
A scoping review on how physical fitness is evaluated in sitting volleyball players
Introduction: Sitting volleyball is a widely practiced paralympic sport. A correct and standardized physical evaluation helps coaches to plan and manage the training. It is also important to evaluate physical fitness accurately and adopt standardized protocols to compare and normalize the data. The aim of the study was to evaluate physical fitness evaluation methods adopted in sitting volleyball and to eventually propose standard operating procedures. Evidence acquisition: English-written and peer-reviewed original articles were included in this review. The population studied was composed only of athletes practicing sitting volleyball. Articles were searched on the electronic databases PubM…
Association between internal load responses and recovery ability in U19 professional soccer players: A machine learning approach
Background The objective of soccer training load (TL) is enhancing players’ performance while minimizing the possible negative effects induced by fatigue. In this regard, monitoring workloads and recovery is necessary to avoid overload and injuries. Given the controversial results found in literature, this study aims to better understand the complex relationship between internal training load (IL) by using rating of perceived exertion (RPE), recovery, and availability (i.e., subjective players’ readiness status). Methods In this cross-sectional study, twenty-two-professional soccer players (age: 18.5 ± 0.4 years, height: 177 ± 6 cm, weight: 67 ± 6.7 kg) competing in the U19 Italian Champion…