0000000000400906

AUTHOR

Karoly Szuhai

0000-0002-1228-4245

showing 2 related works from this author

Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone

2012

Abstract Background Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome. In pre-clinical research aiming at the identification of novel treatment targets, the need for representative cell lines and model systems is high, but availability is scarce. Methods We developed and characterized three cell lines, derived from conventional grade III chondrosarcoma (L835), and dedifferentiated chondrosarcoma (L2975 and L3252) of bone. Proliferation and migration were studied and we used COBRA-FISH and array-CGH for karyotyping and genotyping. Immunohistochemistry for p16 and p53 was performed a…

MaleBone neoplasmCancer ResearchPathologymedicine.medical_specialtyIDH1Transplantation HeterologousChondrosarcomaMice NudeBone Neoplasmsp16Bone neoplasmlcsh:RC254-282MiceTreatment targetsCell MovementCell Line TumorGeneticsmedicineAnimalsHumansDedifferentiated chondrosarcomaIn Situ Hybridization FluorescenceComparative Genomic HybridizationNeoplasm Gradingbusiness.industryConventional ChondrosarcomaMiddle Agedlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseRadiographyRadiusOncologyMutationIDH1IDH2Neoplasm GradingChondrosarcomaCell linebusinessPrimary sarcomaResearch ArticleBMC Cancer
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1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

2012

12 páginas, 6 figuras, 1 tabla.-- et al.

AdultMaleCancer ResearchCandidate geneAdolescentDNA Copy Number VariationsUbiquitin-Protein Ligasesclinical outcomeBone NeoplasmsSarcoma EwingBiologyBioinformaticsPolymorphism Single NucleotideTranscriptomeIn vivoCell Line TumorGeneticsmedicineHumansChildMolecular BiologymicroarraysAgedCell ProliferationAged 80 and overCell CycleComputational BiologyInfantNuclear ProteinsMiddle Agedmedicine.disease1q GainIn vitroChromosomes Human Pair 1Child PreschoolCancer researchImmunohistochemistryFemaleCDT2SarcomaDNA microarrayEwing sarcomaComparative genomic hybridization
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