0000000000403481

AUTHOR

Luigi Marchionni

showing 2 related works from this author

Look for methods, not conclusions

2019

Qualunque sia l'esito effettivo di un'indagine su un caso di presunta manipolazione dei dati, ci sono alcuni principi fermi che sono sempre veri e alcuni errori che devono essere evitati.

Cancer ResearchMolecular biologyPeer ReviewScienceImmunologyScientific MisconductSettore AGR/13 - Chimica Agrariamethods; verification experimental datasetresearch integrityDiseasesmethodsCellular and Molecular NeuroscienceCorrespondenceScientific methodHumansexperimental datasetlcsh:QH573-671Scientific misconductPeer Review Researchlcsh:CytologyResearchCell BiologyEngineering ethicsverificationPsychologyHumans; Peer Review Research; Science; Scientific Misconduct
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CALANGO: a phylogeny-aware comparative genomics tool for discovering quantitative genotype-phenotype associations across species

2023

The increasing availability of high-quality genomic, annotation and phenotypic data for different species contrasts with the lack of general software for comparative genomics that integrates these data types in a statistically sound framework in order to produce biologically meaningful knowledge. In this work, we present CALANGO (Comparative AnaLysis with ANnotation-based Genomic cOmponentes), a first-principles comparative genomics tool to search for annotation terms, such as GO terms or Pfam domain IDs, associated with a quantitative variable used to rank species data, after correcting for phylogenetic relatedness. This information can be used to annotate genomes at any level, including p…

Comparative genomicsAnnotationPhylogeneticsIn silicoHorizontal gene transferGeneral Decision SciencesVirulenceComputational biologyBiologyGenomeProphage
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