0000000000409188

AUTHOR

Dominic Yu

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Computer-assisted image analysis of liver collagen: relationship to Ishak scoring and hepatic venous pressure gradient.

2009

Histopathological scoring of disease stage uses descriptive categories without measuring the amount of fibrosis. Collagen, the major component of fibrous tissue, can be quantified by computer-assisted digital image analysis (DIA) using histological sections. We determined relationships between DIA, Ishak stage, and hepatic venous pressure gradient (HVPG) reflecting severity of fibrosis. One hundred fifteen patients with hepatitis C virus (HCV) who had undergone transplantation had 250 consecutive transjugular liver biopsies combined with HVPG (median length, 22 mm; median total portal tracts, 12), evaluated using the Ishak system and stained with Sirus red for DIA. Liver collagen was expres…

AdultLiver CirrhosisMalemedicine.medical_specialtyCirrhosismedicine.medical_treatmentPortal venous pressureImage ProcessingBiopsyLiver transplantationHepatic VeinsGastroenterologyComputer-AssistedInternal medicineBiopsymedicineImage Processing Computer-AssistedHumansProspective StudiesAgedHepatologymedicine.diagnostic_testbusiness.industryHepatologyMiddle Agedmedicine.diseaseHepatitis CConfidence intervalSurgeryLiver TransplantationTransplantationLogistic ModelsLiverAdult; Aged; Biopsy; Collagen; Female; Hepatic Veins; Hepatitis C; Humans; Liver; Liver Cirrhosis; Liver Transplantation; Logistic Models; Male; Middle Aged; Prospective Studies; Venous Pressure; Image Processing Computer-AssistedFemaleCollagenTransient elastographybusinessVenous Pressurecollagen proportionate area HVPG liver fibrosisHepatology (Baltimore, Md.)
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