Author: Vardan Amirbekian

0000000000410146

AUTHOR

Vardan Amirbekian

showing 1 related works from this author

Macrophage-Specific Lipid-Based Nanoparticles Improve Cardiac Magnetic Resonance Detection and Characterization of Human Atherosclerosis

2009

ObjectivesWe sought to determine whether gadolinium (Gd)-containing lipid-based nanoparticles (NPs) targeting the macrophage scavenger receptor-B (CD36) improve cardiac magnetic resonance (CMR) detection and characterization of human atherosclerosis.BackgroundGd-containing lipid-based NPs targeting macrophages have improved MR detection of murine atherosclerosis.MethodsGadolinium-containing untargeted NPs, anti-CD36 NPs, and nonspecific Fc-NPs were created. Macrophages were incubated with fluorescent targeted and nontargeted NPs to determine uptake via confocal microscopy and inductively coupled plasma mass spectroscopy (ICP-MS) quantified Gd uptake. Human aortic specimens were harvested at…

CD36 AntigensGadoliniumCD36Contrast Media030204 cardiovascular system & hematology030218 nuclear medicine & medical imaging0302 clinical medicineHeterocyclic CompoundsMacrophageMacrophage Scavenger Receptorhealth care economics and organizationsCells CulturedMicroscopy Confocalmedicine.diagnostic_testbiologyrespiratory systemImmunohistochemistryLipidsMagnetic Resonance ImagingRadiology Nuclear Medicine and imagingcardiovascular systemAutopsyCardiology and Cardiovascular Medicinetherapeuticscirculatory and respiratory physiologyinorganic chemicalsAortic Diseaseschemistry.chemical_elementmacrophageAortic diseaseArticle03 medical and health sciencesPredictive Value of TestsLipid based nanoparticlesmedicineOrganometallic CompoundsHumansRadiology Nuclear Medicine and imagingcardiovascular diseasesbusiness.industryMacrophagesSpectrophotometry Atomictechnology industry and agricultureMagnetic resonance imagingBiological TransportAtherosclerosischemistryCancer researchbiology.proteinNanoparticlesCD36Cardiac magnetic resonancebusinessJACC: Cardiovascular Imaging

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PEPhysical Sciences and Engineering
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LSLife Sciences
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