0000000000412727

AUTHOR

Suarez A.

showing 2 related works from this author

Intraperitoneal drain placement and outcomes after elective colorectal surgery: International matched, prospective, cohort study

2022

Abstract Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and tim…

AdultElective Surgical ProcedureAdult; Aged; Cohort Studies; Drainage; Elective Surgical Procedures; Female; Humans; Postoperative Complications; Prospective Studies; Surgical Wound Infection; Colorectal Surgerydrain; intrabdominaldrainAdult Aged Cohort Studies Colorectal Surgery Drainage Elective Surgical Procedures Female Humans Postoperative Complications Prospective Studies Surgical Wound InfectionSettore MED/18Cohort StudiesSettore MED/18 - Chirurgia GeneraleProspective StudiePostoperative ComplicationsElective Surgical ProceduresintrabdominalDrainageHumansSurgical Wound InfectionSurgeryFemalePostoperative ComplicationProspective StudiesCohort Studiedrain intrabdominalColorectal SurgeryHumanAged
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Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

2020

Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immunosuppression in multiple myeloma (MM). However, their phenotype is not well established for accurate monitoring or clinical translation. We aimed to provide the phenotypic profile of G-MDSCs based on their prognostic significance in MM, immunosuppressive potential, and molecular program. The preestablished phenotype of G-MDSCs was evaluated in bone marrow samples from controls and MM patients using multidimensional flow cytometry; surprisingly, we found that CD11b+CD14−CD15+CD33+HLADR− cells overlapped with common eosinophils and neutrophils, which were not expanded in MM patients. Therefore, we relied on …

MaleTranscription GeneticNeutrophilsT-LymphocytesImmunologyCD33BiologyCD16BiochemistryFollow-Up StudieFlow cytometryAntigens CDmedicineHumansCytotoxic T cellLymphocyte CountTumor microenvironmentmedicine.diagnostic_testMyeloid-Derived Suppressor CellsCell BiologyHematologyMiddle AgedCell sortingNeoplasm Proteinsmedicine.anatomical_structureT-LymphocyteCancer researchMyeloid-derived Suppressor CellFemaleBone marrowMultiple MyelomaHumanFollow-Up StudiesBlood
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