0000000000413336

AUTHOR

Eman H. Reda

showing 3 related works from this author

Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

2018

Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1&ndash

Pharmaceutical ScienceTumor cells01 natural sciencesAnalytical ChemistryTDDTF-ECDlcsh:QD241-441tumor anti-proliferative activitylcsh:Organic chemistryDrug DiscoveryPhysical and Theoretical ChemistrySolvent extractionA549 cellEuphorbiabiologyTraditional medicine010405 organic chemistryChemistryOrganic ChemistryEuphorbiaceaeEuphorbiaceaediterpenesEuphorbia sanctae-catharinaebiology.organism_classification0104 chemical sciences010404 medicinal & biomolecular chemistryChemistry (miscellaneous)flavonoidsMolecular Medicine<i>Euphorbia sanctae-catharinae</i>Molecules
researchProduct

Evaluation of genetic variability and relatedness among eight Centaurea species through CAAT-box derived polymorphism (CBDP) and start codon targeted…

2021

Centaurea is a value-ultimate genus of medicinal plants showing high diversification levels, especially within the Mediterranean basin, and is still traditionally recognized as a complicated taxon. So far, few studies utilizing molecular markers have been done on Centaurea spp. towards a better dissection of its phylogeny and accurate assessment of genetic diversity. Here, two functional marker systems, start codon targeted (SCoT) polymorphism and CAAT box-derived polymorphism (CBDP), were implemented to assess the genetic diversity between eight wild Centaurea species in Egypt. Seventeen SCoT and 19 CBDP primers generated 197 and 179 bands, respectively. These primers generated 158 (80.2%)…

Genetic diversitybiologymolecular markersfungicentaureagenetic diversitybiology.organism_classificationMediterranean BasinTaxonStart codonpcrCentaureaEvolutionary biologyGenusPolymorphism (computer science)cbdpscotGenetic variabilityTP248.13-248.65BiotechnologyBiotechnology & Biotechnological Equipment
researchProduct

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

2019

Abstract Background The multidrug resistance (MDR) phenotype encounters a major challenge to the success of established chemotherapy in cancer patients. We hypothesized that cytotoxic medicinal plants with novel phytochemicals can overcome MDR and kill MDR-cells with similar efficacy as drug sensitive cells. Purpose We evaluated plant extracts from an unexplored ecosystem in Egypt with unusual climate and nutrient conditions for their activity against sensitive and multidrug-resistant cancer cell lines. Material and methods/study design Methylene chloride: methanol (1:1) and methanol: H2O (7:3) extracts of 40 plants were prepared resulting in a sum of 76 fraction containing compounds with v…

Programmed cell deathCell SurvivalPhytochemicalsPharmaceutical ScienceApoptosisCentaureaWithaniaPulicariaMagnoliopsida03 medical and health sciences0302 clinical medicineCell Line TumorNeoplasmsDrug DiscoveryHumansCytotoxic T cellViability assayCytotoxicity030304 developmental biologyMembrane Potential MitochondrialPharmacology0303 health sciencesPlants MedicinalbiologyPlant ExtractsChemistryWithaniabiology.organism_classificationAntineoplastic Agents PhytogenicMolecular biologyDrug Resistance MultipleMultiple drug resistanceComplementary and alternative medicineDrug Resistance NeoplasmCell culture030220 oncology & carcinogenesisCancer cellMolecular MedicineEgyptReactive Oxygen SpeciesPhytotherapyPhytomedicine
researchProduct