0000000000413702

AUTHOR

Nicholas Lease

showing 3 related works from this author

Potential anticancer heterometallic Fe-Au and Fe-Pd agents: Initial mechanistic insights

2013

A series of gold(III) and palladium(II) heterometallic complexes with new iminophosphorane ligands derived from ferrocenylphosphanes [{Cp-P(Ph2)═N-Ph}2Fe] (1), [{Cp-P(Ph2)═N-CH2-2-NC5H4}2Fe] (2), and [{Cp-P(Ph2)═N-CH2-2-NC5H4}Fe(Cp)] (3) have been synthesized and structurally characterized. Ligands 2 and 3 afford stable coordination complexes [AuCl2(3)]ClO4, [{AuCl2}2(2)](ClO4)2, [PdCl2(3)], and [{PdCl2}2(2)]. The complexes have been evaluated for their antiproliferative properties in human ovarian cancer cells sensitive and resistant to cisplatin (A2780S/R), in human breast cancer cells (MCF7) and in a nontumorigenic human embryonic kidney cell line (HEK-293T). The highly cytotoxic trimeta…

STRUCTURAL-CHARACTERIZATIONARENE-RUTHENIUM COMPLEXESStereochemistryANTITUMOR-ACTIVITYchemistry.chemical_elementGOLD COMPOUNDSAntineoplastic AgentsCYTOTOXIC ACTIVITYArticleCoordination ComplexesCell Line TumorDrug DiscoveryOrganometallic CompoundsmedicineHumansCytotoxic T cellFerrous CompoundsBIOLOGICAL-PROPERTIESGroup 2 organometallic chemistryCisplatinHEK 293 cellsIn vitroPLATINUM(II) COMPLEXESHEK293 CellschemistryCELL-DEATHCell cultureCancer cellMolecular MedicineMETAL-COMPLEXESCisplatinOrganogold CompoundsPalladiumX-RAY-STRUCTUREPalladiummedicine.drug
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CCDC 930540: Experimental Crystal Structure Determination

2016

Related Article: Nicholas Lease, Vadim Vasilevski, Monica Carreira, Andreia de Almeida, Mercedes Sanaú, Pipsa Hirva, Angela Casini, María Contel|2013|J.Med.Chem.|56|5806|doi:10.1021/jm4007615

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinatesdichloro-(2-(((triphenylphosphoranylidene)amino)methyl)pyridine)-palladium(ii) chloroform solvate
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CCDC 930539: Experimental Crystal Structure Determination

2016

Related Article: Nicholas Lease, Vadim Vasilevski, Monica Carreira, Andreia de Almeida, Mercedes Sanaú, Pipsa Hirva, Angela Casini, María Contel|2013|J.Med.Chem.|56|5806|doi:10.1021/jm4007615

Space GroupCrystallographydichloro-(2-(((diphenyl(ferrocenyl)phosphoranylidene)amino)methyl)pyridine)-palladium(ii) methanol solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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