0000000000414267

AUTHOR

M. Simoni

showing 5 related works from this author

Third-hand smoke exposure and health hazards in children

2013

Smoking still represents a huge public health problem. Millions of children suffer the detrimental effects of passive smoking. An increasing number of countries have recently issued laws to regulate smoking in public places. Instead, homes remain a site where children are dangerously exposed to environmental tobacco smoke (ETS). The combination of tobacco smoke pollutants which remain in an indoor environment, the so-called ‘third-hand smoke’ (THS), represent a new concept in the field of tobacco control. THS consists of pollutants that remain on surfaces and in dust after tobacco has been smoked, are re-emitted into the gas-phase, or react with other compounds in the environment to form se…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyPassive smokinglcsh:MedicineSettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.disease_causeTobacco smokeHazardous SubstancesThird-hand smokeSettore MED/38 - Pediatria Generale E SpecialisticaEnvironmental tobacco smokeEnvironmental healthmedicineHumansEnvironmental tobacco smoke Children Lung development Asthma Tobacco control Indoor environment Third-hand smoke.Active smokingThird-hand smokeChildChildrenSmokebusiness.industryPublic healthTobacco controllcsh:RIndoor environmentThird-hand smoke.AsthmaHuman exposureLung developmentTobacco Smoke PollutionTobacco controlCardiology and Cardiovascular Medicinebusiness
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Effects of pet exposure in the first year of life on respiratory and allergic symptoms in 7-yr-old children. The SIDRIA-2 study

2010

Lombardi E, Simoni M, La Grutta S, Viegi G, Bisanti L, Chellini E, Dell’Orco V, Migliore E, Petronio MG, Pistelli R, Rusconi F, Sestini P, Forastiere F, Galassi C and the SIDRIA-2 Collaborative Group. Effects of pet exposure in the first year of life on respiratory and allergic symptoms in 7-yr-old children. The SIDRIA-2 study. Pediatr Allergy Immunol 2010: 21: 268–276. © 2009 John Wiley & Sons A/S The effects of pet exposure on the development of respiratory symptoms have recently been the matter of vivid discussion. Our objective was to determine the effects of exposure to cat or dog in the first year of life on subsequent respiratory/allergic symptoms in children in a large Italian multi…

MaleAllergyPediatricsPassive smokingRespiratory Tract DiseasesEczemamedicine.disease_causeAnimals; Respiratory Sounds; Fungi; Humans; Asthma; Rhinitis; Child; Eczema; Italy; Smoking; Hypersensitivity; Respiratory Tract Diseases; Risk Factors; Cats; Environmental Exposure; Dogs; Female; MaleRisk FactorsDogImmunology and AllergyFamily historyChildRespiratory Tract DiseaseRhinitiRhinitismedicine.diagnostic_testRespiratory diseaseSmokingCatschoolchildrenEnvironmental exposureItalyFemaleepidemiologyHumanmedicine.medical_specialtyImmunologyDogsmedicineHypersensitivityAnimalsHumansRespiratory soundsRisk factorAsthmaRespiratory Soundsasthma; schoolchildren; epidemiologybusiness.industryAnimalRisk FactorFungiEnvironmental Exposureasthmamedicine.diseasePediatrics Perinatology and Child HealthImmunologyCatsRespiratory Soundbusiness
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Longitudinal Asthma Patterns in Italian Adult General Population Samples: Host and Environmental Risk Factors.

2020

Background: Asthma patterns are not well established in epidemiological studies. Aim: To assess asthma patterns and risk factors in an adult general population sample. Methods: In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011–2014). Latent transition analysis (LTA) was performed to detect baseline and 12-month follow-up asthma phenotypes and longitudinal patterns. Risk factors associated with longitudinal patterns were assessed through multinomial logistic regression. Results: LTA detected four longitudinal patterns: persistent asthma diagnosis with symptoms, 27.2%

medicine.medical_specialtyPopulationlcsh:MedicinecomorbiditiesArticle03 medical and health sciences0302 clinical medicineEnvironmental riskInternal medicineEpidemiologymedicine030212 general & internal medicineeducationAsthmaMultinomial logistic regressionvehicular trafficeducation.field_of_studybusiness.industrylcsh:RAsthma symptomslatent transition analysisGeneral Medicinecohortasthmamedicine.diseaserespiratory tract diseases030228 respiratory systemsmokeasthma; epidemiology; cohort; latent transition analysis; comorbidities; smoke; vehicular trafficCohortLatent transition analysisepidemiologybusinessJournal of clinical medicine
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Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children

2006

There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing.To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children.We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers.Of the children, 9.5% (1,478) had transient early wheezing, 5.4% (884) had persistent wheezing, and 6.1% (948) had late-onset wheezing. Maternal hypertension or preeclampsia was associated with an increased risk of all three wheezing phenotypes (for transient early wheezi…

Pulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPopulationPerinatalCritical Care and Intensive Care Medicineasthma; perinatal; programmingPregnancyRisk FactorsIntensive careAsthma; Perinatal; Programming; Child; Female; Humans; Pregnancy; Respiratory Sounds; Risk Factors; Pregnancy Complications; Medicine (all); Pulmonary and Respiratory Medicine; Critical Care and Intensive Care MedicineMaternal hypertensionMedicineHumansRespiratory Sounds; Pregnancy Complications; Risk Factors; Humans; Child; Female; PregnancyRespiratory soundseducationChildAsthmaRespiratory SoundsPregnancyeducation.field_of_studymedicine.diagnostic_testbusiness.industryRisk FactorMedicine (all)Odds ratiomedicine.diseasePregnancy ComplicationAsthmaPregnancy ComplicationsProgrammingGestationFemaleRespiratory SoundbusinessHuman
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GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWA…

2013

INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) a…

MaleKallmann syndromeEndocrinology Diabetes and MetabolismClinical BiochemistryInositol Phosphatemedicine.disease_causeBiochemistryHypogonadotropic hypogonadismGermlineReceptors G-Protein-CoupledCohort StudiesEndocrinologySettore MED/38 - Pediatria Generale E SpecialisticaAdolescent; Adult; Child; Cohort Studies; Cyclic AMP; Female; Genetic Association Studies; Humans; Hypogonadism; Inositol Phosphates; Male; Middle Aged; Mutation Missense; Receptors G-Protein-Coupled; Receptors Peptide; Signal Transduction; Young Adult; Germ-Line MutationReceptorsCyclic AMPmutations; Kallmann syndrome; septo-optic dysplasiaMissense mutationReceptorChildMutationMiddle AgedProkineticinPeptideFemaleHumanSignal TransductionAdultmedicine.medical_specialtyReceptors PeptideAdolescentAdolescent Adult Child Cohort Studies Cyclic AMP; metabolism Female Genetic Association Studies Germ-Line Mutation Humans Hypogonadism; epidemiology/genetics Inositol Phosphates; metabolism Male Middle Aged Missense Receptors; G-Protein-Coupled; genetics Receptors; Peptide; genetics Signal Transduction; genetics Young AdultInositol PhosphatesMutation MissenseGenetic Association StudieBiologyG-Protein-CoupledYoung AdultGermline mutationInternal medicinesepto-optic dysplasiamedicineHumansGenetic Association StudiesGerm-Line MutationHypogonadismBiochemistry (medical)Kallmann syndromeProkineticin receptor 2medicine.diseasePROKR2 hypogonadism prokineticinmutationsAdolescent; Adult; Child; Cohort Studies; Cyclic AMP; Female; Genetic Association Studies; Humans; Hypogonadism; Inositol Phosphates; Male; Middle Aged; Mutation; Missense; Receptors; G-Protein-Coupled; Peptide; Signal Transduction; Young Adult; Germ-Line MutationEndocrinologyMutationCohort StudieMissense
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