0000000000414316

AUTHOR

Carina Gabriela Uasuf

showing 4 related works from this author

Tropomyosin: A panallergen that causes a worldwide allergic problem

2021

Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symp…

Pulmonary and Respiratory Medicineinsect allergymacromolecular substancesCross Reactionsmedicine.disease_causeImmunoglobulin EConserved sequencetropomyosinAllergenFood allergybiology.animalmedicineImmunology and AllergyHumansAmino Acid Sequenceseafood allergyGeneticsfood allergybiologybusiness.industryVertebrateGeneral MedicineArticlesAllergensImmunoglobulin Emedicine.diseasemusculoskeletal systemTropomyosinIgE cross-reactivitypanallergenAllergic responsebiology.proteinhouse-dust mite allergyAllergistsbusinesstissuesFood Hypersensitivity
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Multiple in vitro and in vivo regulatory effects of budesonide in CD4+ T lymphocyte subpopulations of allergic asthmatics.

2012

Abstract BACKGROUND: Increased activation and increased survival of T lymphocytes characterise bronchial asthma. OBJECTIVES: In this study the effect of budesonide on T cell survival, on inducible co-stimulator T cells (ICOS), on Foxp3 and on IL-10 molecules in T lymphocyte sub-populations was assessed. METHODS: Cell survival (by annexin V binding) and ICOS in total lymphocytes, in CD4+/CD25+ and in CD4+/CD25- and Foxp3 and IL-10 in CD4+/CD25+ and in CD4+/CD25-cells was evaluated, by cytofluorimetric analysis, in mild intermittent asthmatics (n = 19) and in controls (n = 15). Allergen induced T lymphocyte proliferation and the in vivo effects of budesonide in mild persistent asthmatics (n =…

BudesonideCD4-Positive T-LymphocytesMalePulmonologylcsh:Medicineimmune system diseasesT-Lymphocyte SubsetsMolecular Cell Biologylcsh:ScienceBudesonidecigarette smoke airway epithelial cells reactive oxygen species.MultidisciplinaryT CellsAllergy and HypersensitivityClinical Pharmacologyhemic and immune systemsForkhead Transcription Factorsrespiratory systemMiddle AgedFlow CytometryBronchodilator AgentsInterleukin-10Interleukin 10MedicineFemalemedicine.drugResearch ArticleAdultDrugs and DevicesAdolescentCell SurvivalImmune CellsImmunologychemical and pharmacologic phenomenaInducible T-Cell Co-Stimulator ProteinImmunomodulationIn vivomedicineHumansInducible T-Cell Co-Stimulator ProteinBiologyAsthmaCell Proliferationbusiness.industrylcsh:RT lymphocytemedicine.diseaseIn vitroAsthmarespiratory tract diseasesApoptosisImmunologylcsh:QClinical ImmunologybusinessCytometryPloS one
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Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells.

2010

Abstract Cigarette smoke extracts (CSE) alter TLR4 expression and activation in bronchial epithelial cells. Cilomilast, a phosphodiesterase-4 inhibitor, inhibits cigarette smoke-induced neutrophilia. This study was aimed to explore whether cilomilast, in a human bronchial epithelial cell line (16-HBE), counteracted CSE effects. In particular, TLR4 expression, IP-10 and IL-8 release, lymphocyte and neutrophil chemotactic activity and ERK and IkBa phosphorylation in CSE and LPS-stimulated 16-HBE were assessed. CSE increased TLR4 expression, reduced IP-10 release and lymphocyte chemotactic activity and increased IL-8 release and neutrophil chemotactic activity. Cilomilast reduced TLR4 expressi…

MAPK/ERK pathwayCyclohexanecarboxylic AcidsLymphocyteImmunologyCyclohexanecarboxylic AcidRespiratory MucosaBiologyCell LineSmokeparasitic diseasesNitrilesmedicineHumansLymphocytesCOPDChemotaxisCilomilastInterleukin-8ChemotaxiChemotaxisTobacco Use Disordermedicine.diseaseNeutrophiliaChemokine CXCL10Toll-Like Receptor 4medicine.anatomical_structureGene Expression RegulationPhosphodiesterase 4 InhibitorImmunologyTLR4PhosphorylationLymphocytePhosphodiesterase 4 Inhibitorsmedicine.symptomNitrileHumanmedicine.drugSignal TransductionCellular immunology
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Use of a comprehensive diagnostic algorithm for Anisakis allergy in a high seroprevalence Mediterranean setting

2020

Summary Background.Diagnosis of anisakis allergy (AA) is based on the skin prick test (SPT) and specific IgE (sIgE) determination. Anyway, false positivity cases are due to cross reactivity with numerous allergens. The aim of the study was to evaluate the reliability of a comprehensive diagnostic algorithm for the AA. Methods.An observational study was conducted on a sample of consecutive subjects accessing the allergology outpatient ambulatories of two hospitals located in Western Sicily. All the recruited outpatients were tested by Skin Prick Test performed using anisakis extracts by ALK-Abello (Madrid, Spain). Specific IgE dosage for anisakis extracts was then performed by using ImmunoCA…

AdultMaleAllergyAdolescentAnisakiBasophil activation testBasophil Degranulation Testmedicine.disease_causeImmunoglobulin EAnisakiasisSettore MED/42 - Igiene Generale E ApplicataCross-reactivityAnisakisYoung AdultFood allergySeroepidemiologic StudiesmedicineHypersensitivityImmunology and AllergySeroprevalenceAnimalsHumansChronic UrticariaImmunocapanisakis allergySkin TestsImmunodiagnosticsfood allergybiologybusiness.industryMediterranean RegionAllergensImmunoglobulin EMiddle Agedmedicine.diseasebiology.organism_classificationAnisakisBasophil activationItalyAntigens Helminthbiology.proteinFemalediagnosis of Anisakis sensitizationbusinessAlgorithmAlgorithms
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