0000000000417267
AUTHOR
Arnaud Desachy
MOESM1 of Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury
Additional file 1: Figure S1. Acute kidney injury (AKI) worsening cases and control matching. Table S1. Main characteristics of matched and unmatched patients. Table S2. Relative contribution individual drugs to the difference in nephrotoxic burden experienced by cases and controls.
Nephrotoxic drug burden among 1001 critically ill patients: impact on acute kidney injury.
Abstract Background Nephrotoxic drug prescription may contribute to acute kidney injury (AKI) occurrence and worsening among critically ill patients and thus to associated morbidity and mortality. The objectives of this study were to describe nephrotoxic drug prescription in a large intensive-care unit cohort and, through a case–control study nested in the prospective cohort, to evaluate the link of nephrotoxic prescription burden with AKI. Results Six hundred and seventeen patients (62%) received at least one nephrotoxic drug, among which 303 (30%) received two or more. AKI was observed in 609 patients (61%). A total of 351 patients were considered as cases developing or worsening AKI a gi…