0000000000418904

AUTHOR

Andrew A. Udy

showing 1 related works from this author

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study

2020

The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first 96 h) osmotherapy in these patients might be associated with a difference in mortality. We retrospectively analyzed data from 2015 from 14 tertiary intensive care units (ICUs) in Australia, UK, and Europe treating severe TBI patients with intracranial pressure (ICP) monitoring and compared mortality in those who received mannitol only versus HTS only. We performed multi-variable analysis adjusting for site and illness severity (Injury Severity Score, extended IMPACT scor…

AdultMale030506 rehabilitationmedicine.medical_specialtyTraumatic brain injurymedicine.medical_treatmentosmotherapy03 medical and health sciences0302 clinical medicineOsmotherapyInternal medicineIntensive careDECOMPRESSIVE CRANIECTOMYBrain Injuries TraumaticHYPERTONIC SALINEmedicineMANAGEMENTHumansEQUIOSMOLARIntracranial pressureRetrospective StudiesSaline Solution Hypertonicbusiness.industryHead Traumatraumatic brain injuryHazard ratio3112 NeurosciencesmannitolMiddle Agedmedicine.disease3126 Surgery anesthesiology intensive care radiologyDiuretics Osmoticmortality3. Good healthHypertonic salineAdult Brain InjuryTreatment Outcome3121 General medicine internal medicine and other clinical medicineInjury Severity ScoreClinical Management of CNS InjuryDecompressive craniectomyFemaleNeurology (clinical)0305 other medical sciencebusinessCONSENSUS030217 neurology & neurosurgeryhypertonic saline
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